Cooperative Functions of ZnT1, Metallothionein and ZnT4 in the Cytoplasm Are Required for Full Activation of TNAP in the Early Secretory Pathway

Shigeyuki Fujimoto; Naoya Itsumura; Tokuji Tsuji; Yasumi Anan; Natsuko Tsuji; Yasumitsu Ogra; Tomoki Kimura; Yusaku Miyamae; Seiji Masuda; Masaya Nagao; Taiho Kambe

doi:10.1371/journal.pone.0077445

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Open Access

Peer-reviewed

Research Article

Cooperative Functions of ZnT1, Metallothionein and ZnT4 in the Cytoplasm Are Required for Full Activation of TNAP in the Early Secretory Pathway

Shigeyuki Fujimoto ,

Contributed equally to this work with: Shigeyuki Fujimoto, Naoya Itsumura

Affiliation Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
⨯
Naoya Itsumura ,

Contributed equally to this work with: Shigeyuki Fujimoto, Naoya Itsumura

Affiliation Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
⨯
Tokuji Tsuji,

Affiliation Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
⨯
Yasumi Anan,

Affiliation Laboratory of Chemical Toxicology and Environmental Health, Showa Pharmaceutical University, Machida, Tokyo, Japan
⨯
Natsuko Tsuji,

Affiliation Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
⨯
Yasumitsu Ogra,

Affiliations Laboratory of Chemical Toxicology and Environmental Health, Showa Pharmaceutical University, Machida, Tokyo, Japan, High Technology Research Center, Showa Pharmaceutical University, Machida, Tokyo, Japan
⨯
Tomoki Kimura,

Affiliation Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan
⨯
Yusaku Miyamae,

Affiliation Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
⨯
Seiji Masuda,

Affiliation Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
⨯
Masaya Nagao,

Affiliation Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
⨯
Taiho Kambe

* E-mail: kambe1@kais.kyoto-u.ac.jp

Affiliation Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
⨯

Cooperative Functions of ZnT1, Metallothionein and ZnT4 in the Cytoplasm Are Required for Full Activation of TNAP in the Early Secretory Pathway

Shigeyuki Fujimoto,
Naoya Itsumura,
Tokuji Tsuji,
Yasumi Anan,
Natsuko Tsuji,
Yasumitsu Ogra,
Tomoki Kimura,
Yusaku Miyamae,
Seiji Masuda,
Masaya Nagao

Published: October 18, 2013
https://doi.org/10.1371/journal.pone.0077445

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