Activation Associated ERK1/2 Signaling Impairments in CD8⁺ T Cells Co-Localize with Blunted Polyclonal and HIV-1 Specific Effector Functions in Early Untreated HIV-1 Infection

• Timothy Q. Crawford,

  Affiliation Hawaii Center for HIV/AIDS, John A. Burns School of Medicine, Department of Tropical Medicine, Medical Microbiology and Pharmacology, University of Hawaii at Manoa, Honolulu, Hawaii, United States of America

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• Fredrick M. Hecht,

  Affiliation HIV/AIDS Division, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America

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• Christopher D. Pilcher,

  Affiliation HIV/AIDS Division, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America

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• Lishomwa C. Ndhlovu,

  Affiliation Hawaii Center for HIV/AIDS, John A. Burns School of Medicine, Department of Tropical Medicine, Medical Microbiology and Pharmacology, University of Hawaii at Manoa, Honolulu, Hawaii, United States of America

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• Jason D. Barbour

  * E-mail: jbarbour@hawaii.edu

  Affiliation Hawaii Center for HIV/AIDS, John A. Burns School of Medicine, Department of Tropical Medicine, Medical Microbiology and Pharmacology, University of Hawaii at Manoa, Honolulu, Hawaii, United States of America

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