The Long Noncoding RNA HOTAIR Contributes to Cisplatin Resistance of Human Lung Adenocarcinoma Cells via downregualtion of p21WAF1/CIP1 Expression

Zhili Liu; Ming Sun; Kaihua Lu; Jing Liu; Meiling Zhang; Weiqin Wu; Wei De; Zhaoxia Wang; Rui Wang

doi:10.1371/journal.pone.0077293

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Open Access

Peer-reviewed

Research Article

The Long Noncoding RNA HOTAIR Contributes to Cisplatin Resistance of Human Lung Adenocarcinoma Cells via downregualtion of p21^WAF1/CIP1 Expression

Zhili Liu ,

Contributed equally to this work with: Zhili Liu, Ming Sun, Kaihua Lu

Affiliation Department of Oncology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
⨯
Ming Sun ,

Contributed equally to this work with: Zhili Liu, Ming Sun, Kaihua Lu

Affiliation Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, P.R. China
⨯
Kaihua Lu ,

Contributed equally to this work with: Zhili Liu, Ming Sun, Kaihua Lu

Affiliation Department of Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
⨯
Jing Liu,

Affiliation Department of Oncology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
⨯
Meiling Zhang,

Affiliation Department of Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
⨯
Weiqin Wu,

Affiliation Department of Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
⨯
Wei De,

Affiliation Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, P.R. China
⨯
Zhaoxia Wang ,

* E-mail: zhaoxiawang88@163.com (ZXW); wangrui1977218@163.com (RW)

Affiliation Department of Oncology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
⨯
Rui Wang

* E-mail: zhaoxiawang88@163.com (ZXW); wangrui1977218@163.com (RW)

Affiliation Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, P.R. China
⨯

The Long Noncoding RNA HOTAIR Contributes to Cisplatin Resistance of Human Lung Adenocarcinoma Cells via downregualtion of p21^WAF1/CIP1 Expression

Zhili Liu,
Ming Sun,
Kaihua Lu,
Jing Liu,
Meiling Zhang,
Weiqin Wu,
Wei De,
Zhaoxia Wang,
Rui Wang

Published: October 14, 2013
https://doi.org/10.1371/journal.pone.0077293

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