Rapid Inhibition of Pyruvate Dehydrogenase: An Initiating Event in High Dietary Fat-Induced Loss of Metabolic Flexibility in the Heart

Open Access

Peer-reviewed

Research Article

Clair Crewe,

Affiliations Free Radical Biology and Aging Research Program Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, United States of America
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Michael Kinter,

Affiliations Free Radical Biology and Aging Research Program Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Department of Geriatric Medicine, Reynolds Center on Aging, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, United States of America
⨯
Luke I. Szweda

* E-mail: Luke-Szweda@omrf.org

Affiliations Free Radical Biology and Aging Research Program Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, United States of America, Department of Geriatric Medicine, Reynolds Center on Aging, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, United States of America
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Diet
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Fats
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Mitochondria
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Pyruvate
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Glucose metabolism
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Heart
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Fatty acids
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Trophic interactions
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