Molecular Characterization of Monoclonal Antibodies that Inhibit Acetylcholinesterase by Targeting the Peripheral Site and Backdoor Region

Yves Bourne; Ludovic Renault; Sosthène Essono; Grégoire Mondielli; Patricia Lamourette; Didier Boquet; Jacques Grassi; Pascale Marchot

doi:10.1371/journal.pone.0077226

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Peer-reviewed

Research Article

Molecular Characterization of Monoclonal Antibodies that Inhibit Acetylcholinesterase by Targeting the Peripheral Site and Backdoor Region

Yves Bourne ,

Contributed equally to this work with: Yves Bourne, Ludovic Renault

Affiliation Architecture et Fonction des Macromolécules Biologiques (AFMB), CNRS/Aix-Marseille Université, Campus Luminy, Marseille, France
⨯
Ludovic Renault ,

Contributed equally to this work with: Yves Bourne, Ludovic Renault

Current address: Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Herts, United Kingdom.

Affiliation Ingénierie des Protéines, CNRS/Aix-Marseille Université, Faculté de Médecine - Secteur Nord, Marseille, France
⨯
Sosthène Essono,

Current address: Pfizer Inc., Cambridge, Massachusetts, United States of America.

Affiliation CEA, iBiTecS, Service de Pharmacologie et Immunologie (SPI), Laboratoire d’Etude et de Recherche en Immunoanalyse (LERI), Gif-sur-Yvette, France
⨯
Grégoire Mondielli,

Affiliation Centre de Recherche en Neurobiologie-Neurophysiologie de Marseille (CRN2M), CNRS/Aix-Marseille Université, Faculté de Médecine - Secteur Nord, Marseille, France
⨯
Patricia Lamourette,

Affiliation CEA, iBiTecS, Service de Pharmacologie et Immunologie (SPI), Laboratoire d’Etude et de Recherche en Immunoanalyse (LERI), Gif-sur-Yvette, France
⨯
Didier Boquet,

Affiliation CEA, iBiTecS, Service de Pharmacologie et Immunologie (SPI), Laboratoire d’Ingénierie des Anticorps pour la Santé (LIAS), Gif-sur-Yvette, France
⨯
Jacques Grassi,

Affiliation CEA, iBiTecS, Service de Pharmacologie et Immunologie (SPI), Laboratoire d’Etude et de Recherche en Immunoanalyse (LERI), Gif-sur-Yvette, France
⨯
Pascale Marchot

* E-mail: pascale.marchot@univ-amu.fr

Affiliations Architecture et Fonction des Macromolécules Biologiques (AFMB), CNRS/Aix-Marseille Université, Campus Luminy, Marseille, France, Ingénierie des Protéines, CNRS/Aix-Marseille Université, Faculté de Médecine - Secteur Nord, Marseille, France, Centre de Recherche en Neurobiologie-Neurophysiologie de Marseille (CRN2M), CNRS/Aix-Marseille Université, Faculté de Médecine - Secteur Nord, Marseille, France
⨯

Molecular Characterization of Monoclonal Antibodies that Inhibit Acetylcholinesterase by Targeting the Peripheral Site and Backdoor Region

Yves Bourne,
Ludovic Renault,
Sosthène Essono,
Grégoire Mondielli,
Patricia Lamourette,
Didier Boquet,
Jacques Grassi,
Pascale Marchot

Published: October 11, 2013
https://doi.org/10.1371/journal.pone.0077226

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