GSTT1 Copy Number Gain and ZNF Overexpression Are Predictors of Poor Response to Imatinib in Gastrointestinal Stromal Tumors

Eui Jin Lee; Guhyun Kang; Shin Woo Kang; Kee-Taek Jang; Jeeyun Lee; Joon Oh Park; Cheol Keun Park; Tae Sung Sohn; Sung Kim; Kyoung-Mee Kim

doi:10.1371/journal.pone.0077219

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Open Access

Peer-reviewed

Research Article

GSTT1 Copy Number Gain and ZNF Overexpression Are Predictors of Poor Response to Imatinib in Gastrointestinal Stromal Tumors

Eui Jin Lee ,

Contributed equally to this work with: Eui Jin Lee, Guhyun Kang

Current address: Department of Pathology, Incheon St. Mary Hospital, The Catholic University of Korea, Incheon, Korea

Affiliation Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯
Guhyun Kang ,

Contributed equally to this work with: Eui Jin Lee, Guhyun Kang

Affiliations Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Department of Pathology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea
⨯
Shin Woo Kang,

Affiliations Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Department of Mathematics, Korea University, Seoul, Korea
⨯
Kee-Taek Jang,

Affiliation Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯
Jeeyun Lee,

Affiliation Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯
Joon Oh Park,

Affiliation Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯
Cheol Keun Park,

Affiliation Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯
Tae Sung Sohn,

Affiliation Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯
Sung Kim,

Affiliation Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯
Kyoung-Mee Kim

* E-mail: kkmkys@skku.ed

Affiliation Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯

GSTT1 Copy Number Gain and ZNF Overexpression Are Predictors of Poor Response to Imatinib in Gastrointestinal Stromal Tumors

Eui Jin Lee,
Guhyun Kang,
Shin Woo Kang,
Kee-Taek Jang,
Jeeyun Lee,
Joon Oh Park,
Cheol Keun Park,
Tae Sung Sohn,
Sung Kim,
Kyoung-Mee Kim

Published: October 4, 2013
https://doi.org/10.1371/journal.pone.0077219

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Gene expression
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Deletion mutation
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Gastrointestinal stromal tumors
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