5-Aminolevulinic Acid Induced Fluorescence Is a Powerful Intraoperative Marker for Precise Histopathological Grading of Gliomas with Non-Significant Contrast-Enhancement

Georg Widhalm; Barbara Kiesel; Adelheid Woehrer; Tatjana Traub-Weidinger; Matthias Preusser; Christine Marosi; Daniela Prayer; Johannes A. Hainfellner; Engelbert Knosp; Stefan Wolfsberger

doi:10.1371/journal.pone.0076988

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Open Access

Peer-reviewed

Research Article

5-Aminolevulinic Acid Induced Fluorescence Is a Powerful Intraoperative Marker for Precise Histopathological Grading of Gliomas with Non-Significant Contrast-Enhancement

Georg Widhalm ,

* E-mail: georg.widhalm@meduniwien.ac.at

Affiliations Department of Neurosurgery, Medical University Vienna, Vienna, Austria, Institute of Neurology, Medical University Vienna, Vienna, Austria, Comprehensive Cancer Center – Central Nervous System Tumours Unit (CCC-CNS), Medical University Vienna, Vienna, Austria
⨯
Barbara Kiesel,

Affiliations Department of Neurosurgery, Medical University Vienna, Vienna, Austria, Comprehensive Cancer Center – Central Nervous System Tumours Unit (CCC-CNS), Medical University Vienna, Vienna, Austria
⨯
Adelheid Woehrer,

Affiliations Institute of Neurology, Medical University Vienna, Vienna, Austria, Comprehensive Cancer Center – Central Nervous System Tumours Unit (CCC-CNS), Medical University Vienna, Vienna, Austria
⨯
Tatjana Traub-Weidinger,

Affiliations Department of Nuclear Medicine, Medical University Vienna, Vienna, Austria, Comprehensive Cancer Center – Central Nervous System Tumours Unit (CCC-CNS), Medical University Vienna, Vienna, Austria
⨯
Matthias Preusser,

Affiliations Department of Internal Medicine 1, Medical University Vienna, Vienna, Austria, Comprehensive Cancer Center – Central Nervous System Tumours Unit (CCC-CNS), Medical University Vienna, Vienna, Austria
⨯
Christine Marosi,

Affiliations Department of Internal Medicine 1, Medical University Vienna, Vienna, Austria, Comprehensive Cancer Center – Central Nervous System Tumours Unit (CCC-CNS), Medical University Vienna, Vienna, Austria
⨯
Daniela Prayer,

Affiliations Department of Radiology, Medical University Vienna, Vienna, Austria, Comprehensive Cancer Center – Central Nervous System Tumours Unit (CCC-CNS), Medical University Vienna, Vienna, Austria
⨯
Johannes A. Hainfellner,

Affiliations Institute of Neurology, Medical University Vienna, Vienna, Austria, Comprehensive Cancer Center – Central Nervous System Tumours Unit (CCC-CNS), Medical University Vienna, Vienna, Austria
⨯
Engelbert Knosp,

Affiliations Department of Neurosurgery, Medical University Vienna, Vienna, Austria, Comprehensive Cancer Center – Central Nervous System Tumours Unit (CCC-CNS), Medical University Vienna, Vienna, Austria
⨯
Stefan Wolfsberger

Affiliations Department of Neurosurgery, Medical University Vienna, Vienna, Austria, Comprehensive Cancer Center – Central Nervous System Tumours Unit (CCC-CNS), Medical University Vienna, Vienna, Austria
⨯

5-Aminolevulinic Acid Induced Fluorescence Is a Powerful Intraoperative Marker for Precise Histopathological Grading of Gliomas with Non-Significant Contrast-Enhancement

Georg Widhalm,
Barbara Kiesel,
Adelheid Woehrer,
Tatjana Traub-Weidinger,
Matthias Preusser,
Christine Marosi,
Daniela Prayer,
Johannes A. Hainfellner,
Engelbert Knosp,
Stefan Wolfsberger

Published: October 18, 2013
https://doi.org/10.1371/journal.pone.0076988

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