An Antimicrobial Peptidomimetic Induces Mucorales Cell Death through Mitochondria-Mediated Apoptosis

E. Magda Barbu; Fazal Shirazi; Danielle M. McGrath; Nathaniel Albert; Richard L. Sidman; Renata Pasqualini; Wadih Arap; Dimitrios P. Kontoyiannis

doi:10.1371/journal.pone.0076981

Loading metrics

Open Access

Peer-reviewed

Research Article

An Antimicrobial Peptidomimetic Induces Mucorales Cell Death through Mitochondria-Mediated Apoptosis

E. Magda Barbu,

Affiliations David H. Koch Center, Department of Genitourinary Medical Oncology, the University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America, Department of Infectious Diseases, the University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Fazal Shirazi,

Affiliation Department of Infectious Diseases, the University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Danielle M. McGrath,

Current address: Center for Infectious and Inflammatory Diseases, Institute of Bioscience and Technology, Texas A&M University Health Science Center, Houston, Texas, United States of America

Affiliation David H. Koch Center, Department of Genitourinary Medical Oncology, the University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Nathaniel Albert,

Affiliation Department of Infectious Diseases, the University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Richard L. Sidman,

Affiliations Harvard Medical School, Boston, Massachusetts, United States of America, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
⨯
Renata Pasqualini ,

* E-mail: dkontoyi@mdanderson.org (DPK); warap@salud.unm.edu (WA); rpasqual@salud.unm.edu (RP)

Current address: Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, United States of America

Affiliation David H. Koch Center, Department of Genitourinary Medical Oncology, the University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Wadih Arap ,

* E-mail: dkontoyi@mdanderson.org (DPK); warap@salud.unm.edu (WA); rpasqual@salud.unm.edu (RP)

Current address: Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, United States of America

Affiliation David H. Koch Center, Department of Genitourinary Medical Oncology, the University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Dimitrios P. Kontoyiannis

* E-mail: dkontoyi@mdanderson.org (DPK); warap@salud.unm.edu (WA); rpasqual@salud.unm.edu (RP)

Affiliation Department of Infectious Diseases, the University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
⨯

An Antimicrobial Peptidomimetic Induces Mucorales Cell Death through Mitochondria-Mediated Apoptosis

E. Magda Barbu,
Fazal Shirazi,
Danielle M. McGrath,
Nathaniel Albert,
Richard L. Sidman,
Renata Pasqualini,
Wadih Arap,
Dimitrios P. Kontoyiannis

Published: October 3, 2013
https://doi.org/10.1371/journal.pone.0076981

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Mitochondria
Is the Subject Area "Mitochondria" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Cell membranes
Is the Subject Area "Cell membranes" applicable to this article?

Thanks for your feedback.
Influenza
Is the Subject Area "Influenza" applicable to this article?

Thanks for your feedback.
Depolarization
Is the Subject Area "Depolarization" applicable to this article?

Thanks for your feedback.
Membrane staining
Is the Subject Area "Membrane staining" applicable to this article?

Thanks for your feedback.
Mitochondrial membrane
Is the Subject Area "Mitochondrial membrane" applicable to this article?

Thanks for your feedback.
Mycelium
Is the Subject Area "Mycelium" applicable to this article?

Thanks for your feedback.