Urea Transporter UT-B Deletion Induces DNA Damage and Apoptosis in Mouse Bladder Urothelium

Zixun Dong; Jianhua Ran; Hong Zhou; Jihui Chen; Tianluo Lei; Weiling Wang; Yi Sun; Guiting Lin; Lise Bankir; Baoxue Yang

doi:10.1371/journal.pone.0076952

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Open Access

Peer-reviewed

Research Article

Urea Transporter UT-B Deletion Induces DNA Damage and Apoptosis in Mouse Bladder Urothelium

Zixun Dong ,

Contributed equally to this work with: Zixun Dong, Jianhua Ran

Affiliation State Key Laboratory of Natural and Biomimetic Drugs, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, and Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China
⨯
Jianhua Ran ,

Contributed equally to this work with: Zixun Dong, Jianhua Ran

Affiliation Department of Anatomy, Neuroscience Research Center, Basic Medical College, Chongqing Medical University, Chongqing, China
⨯
Hong Zhou,

Affiliation State Key Laboratory of Natural and Biomimetic Drugs, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, and Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China
⨯
Jihui Chen,

Affiliation State Key Laboratory of Natural and Biomimetic Drugs, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, and Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China
⨯
Tianluo Lei,

Affiliation State Key Laboratory of Natural and Biomimetic Drugs, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, and Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China
⨯
Weiling Wang,

Affiliation State Key Laboratory of Natural and Biomimetic Drugs, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, and Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China
⨯
Yi Sun,

Affiliation State Key Laboratory of Natural and Biomimetic Drugs, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, and Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China
⨯
Guiting Lin,

Affiliation Department of Urology, University of California San Francisco, San Francisco, California, United States of America
⨯
Lise Bankir,

Affiliation INSERM Unit 872, Centre de Recherche des Cordeliers, Paris, France
⨯
Baoxue Yang

* E-mail: baoxue@bjmu.edu.cn

Affiliation State Key Laboratory of Natural and Biomimetic Drugs, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, and Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China
⨯

Urea Transporter UT-B Deletion Induces DNA Damage and Apoptosis in Mouse Bladder Urothelium

Zixun Dong,
Jianhua Ran,
Hong Zhou,
Jihui Chen,
Tianluo Lei,
Weiling Wang,
Yi Sun,
Guiting Lin,
Lise Bankir,
Baoxue Yang

Published: October 21, 2013
https://doi.org/10.1371/journal.pone.0076952

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Bladder
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Urea
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Urothelium
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DNA damage
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