Persistent STAT5 Phosphorylation and Epigenetic Dysregulation of GM-CSF and PGS2/COX2 Expression in Type 1 Diabetic Human Monocytes

Erin Garrigan; Nicole S. Belkin; John J. Alexander; Zhao Han; Federica Seydel; Jamal Carter; Mark Atkinson; Clive Wasserfall; Michael J. Clare-Salzler; Matthew A. Amick; Sally A. Litherland

doi:10.1371/journal.pone.0076919

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Peer-reviewed

Research Article

Persistent STAT5 Phosphorylation and Epigenetic Dysregulation of GM-CSF and PGS2/COX2 Expression in Type 1 Diabetic Human Monocytes

Erin Garrigan,

Affiliation Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida, United States of America
⨯
Nicole S. Belkin,

Current address: Dept. of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Affiliation Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida, United States of America
⨯
John J. Alexander,

Current address: Dept of Vision Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Affiliation Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida, United States of America
⨯
Zhao Han,

Affiliation Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida, United States of America
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Federica Seydel,

Current address: Dept of Pathology University of California San Francisco, San Francisco, California, United States of America

Affiliation Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida, United States of America
⨯
Jamal Carter,

Affiliation Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida, United States of America
⨯
Mark Atkinson,

Affiliation Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida, United States of America
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Clive Wasserfall,

Affiliation Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida, United States of America
⨯
Michael J. Clare-Salzler,

Affiliation Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida, United States of America
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Matthew A. Amick,

Affiliation Sanford-Burnham Medical Research Institute Orlando, Orlando, Florida, United States of America
⨯
Sally A. Litherland

* E-mail: Sally.Litherland@flhosp.org

Affiliations Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida, United States of America, Sanford-Burnham Medical Research Institute Orlando, Orlando, Florida, United States of America
⨯

Persistent STAT5 Phosphorylation and Epigenetic Dysregulation of GM-CSF and PGS2/COX2 Expression in Type 1 Diabetic Human Monocytes

Erin Garrigan,
Nicole S. Belkin,
John J. Alexander,
Zhao Han,
Federica Seydel,
Jamal Carter,
Mark Atkinson,
Clive Wasserfall,
Michael J. Clare-Salzler,
Matthew A. Amick

Published: October 18, 2013
https://doi.org/10.1371/journal.pone.0076919

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Monocytes
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Epigenetics
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Binding analysis
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Histones
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Gene regulation
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Inflammation
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Gene expression
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DNA-binding proteins
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