Fatty Liver Is Associated with Transcriptional Downregulation of Stearoyl-CoA Desaturase and Impaired Protein Dimerization

Tomas Fernández Gianotti; Adriana Burgueño; Noelia Gonzales Mansilla; Carlos Jose Pirola; Silvia Sookoian

doi:10.1371/journal.pone.0076912

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Research Article

Fatty Liver Is Associated with Transcriptional Downregulation of Stearoyl-CoA Desaturase and Impaired Protein Dimerization

Tomas Fernández Gianotti,

Affiliation Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires-National Council of Scientific and Technological Research (CONICET), Ciudad Autónoma de Buenos Aires, Argentina
⨯
Adriana Burgueño,

Affiliation Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires-National Council of Scientific and Technological Research (CONICET), Ciudad Autónoma de Buenos Aires, Argentina
⨯
Noelia Gonzales Mansilla,

Affiliation Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires-National Council of Scientific and Technological Research (CONICET), Ciudad Autónoma de Buenos Aires, Argentina
⨯
Carlos Jose Pirola ,

Contributed equally to this work with: Carlos Jose Pirola, Silvia Sookoian

* E-mail: sookoian.silvia@lanari.fmed.uba.ar (SS); pirola.carlos@lanari.fmed.uba.ar (CJP)

Affiliation Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires-National Council of Scientific and Technological Research (CONICET), Ciudad Autónoma de Buenos Aires, Argentina
⨯
Silvia Sookoian

Contributed equally to this work with: Carlos Jose Pirola, Silvia Sookoian

* E-mail: sookoian.silvia@lanari.fmed.uba.ar (SS); pirola.carlos@lanari.fmed.uba.ar (CJP)

Affiliation Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires-National Council of Scientific and Technological Research (CONICET), Ciudad Autónoma de Buenos Aires, Argentina
⨯

Fatty Liver Is Associated with Transcriptional Downregulation of Stearoyl-CoA Desaturase and Impaired Protein Dimerization

Tomas Fernández Gianotti,
Adriana Burgueño,
Noelia Gonzales Mansilla,
Carlos Jose Pirola,
Silvia Sookoian

Published: September 30, 2013
https://doi.org/10.1371/journal.pone.0076912

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Fatty liver
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Diet
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Protein expression
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Fatty acids
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Adipose tissue
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Dimerization
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Messenger RNA
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