Heterotrimeric G-Protein, Gα16, Is a Critical Downstream Effector of Non-Canonical Wnt Signaling and a Potent Inhibitor of Transformed Cell Growth in Non Small Cell Lung Cancer

Sreedevi Avasarala; Rama Kamesh Bikkavilli; Michelle Van Scoyk; Wei Zhang; Ajibike Lapite; Logan Hostetter; Joshua T. Byers; Lynn E. Heasley; Jang Won Sohn; Robert A. Winn

doi:10.1371/journal.pone.0076895

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Peer-reviewed

Research Article

Heterotrimeric G-Protein, G_α16, Is a Critical Downstream Effector of Non-Canonical Wnt Signaling and a Potent Inhibitor of Transformed Cell Growth in Non Small Cell Lung Cancer

Sreedevi Avasarala,

Affiliation Department of Pulmonary, Critical Care, Sleep and Allergy, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Rama Kamesh Bikkavilli,

Affiliation Department of Pulmonary, Critical Care, Sleep and Allergy, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Michelle Van Scoyk,

Affiliation Department of Pulmonary, Critical Care, Sleep and Allergy, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Wei Zhang,

Affiliation Department of Pediatrics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
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Ajibike Lapite,

Affiliation Department of Pulmonary, Critical Care, Sleep and Allergy, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Logan Hostetter,

Affiliation Department of Pulmonary, Critical Care, Sleep and Allergy, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Joshua T. Byers,

Affiliation Department of Pulmonary, Critical Care, Sleep and Allergy, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
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Lynn E. Heasley,

Affiliation Department of Craniofacial Biology, Anschutz Medical Campus, University of Colorado, Denver, Colorado, United States of America
⨯
Jang Won Sohn,

Affiliation Department of Internal Medicine, School of Medicine, Hanyang University, Seoul, South Korea
⨯
Robert A. Winn

* E-mail: rwinn@uic.edu

Affiliations Department of Pulmonary, Critical Care, Sleep and Allergy, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, United States of America
⨯

Heterotrimeric G-Protein, G_α16, Is a Critical Downstream Effector of Non-Canonical Wnt Signaling and a Potent Inhibitor of Transformed Cell Growth in Non Small Cell Lung Cancer

Sreedevi Avasarala,
Rama Kamesh Bikkavilli,
Michelle Van Scoyk,
Wei Zhang,
Ajibike Lapite,
Logan Hostetter,
Joshua T. Byers,
Lynn E. Heasley,
Jang Won Sohn,
Robert A. Winn

Published: October 18, 2013
https://doi.org/10.1371/journal.pone.0076895

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Non-small cell lung cancer
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G-protein signaling
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PPAR signaling
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Small interfering RNA
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Cell proliferation
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Transfection
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Cell growth
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Small cell lung cancer
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