Blocking KCa3.1 Channels Increases Tumor Cell Killing by a Subpopulation of Human Natural Killer Lymphocytes

Shyny Koshy; Danli Wu; Xueyou Hu; Rajeev B. Tajhya; Redwan Huq; Fatima S. Khan; Michael W. Pennington; Heike Wulff; Patricia Yotnda; Christine Beeton

doi:10.1371/journal.pone.0076740

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Peer-reviewed

Research Article

Blocking KCa3.1 Channels Increases Tumor Cell Killing by a Subpopulation of Human Natural Killer Lymphocytes

Shyny Koshy,

Affiliation Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Danli Wu,

Affiliation Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Xueyou Hu,

Affiliation Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Rajeev B. Tajhya,

Affiliations Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, United States of America, Graduate Program in Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Redwan Huq,

Affiliations Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, United States of America, Graduate Program in Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Fatima S. Khan,

Affiliation Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Michael W. Pennington,

Affiliation Peptides International, Louisville, Kentucky, United States of America
⨯
Heike Wulff,

Affiliation Department of Pharmacology, University of California, Davis, California, United States of America
⨯
Patricia Yotnda ,

Contributed equally to this work with: Patricia Yotnda, Christine Beeton

Affiliation Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Christine Beeton

Contributed equally to this work with: Patricia Yotnda, Christine Beeton

* E-mail: beeton@bcm.edu

Affiliation Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, United States of America
⨯

Blocking KCa3.1 Channels Increases Tumor Cell Killing by a Subpopulation of Human Natural Killer Lymphocytes

Shyny Koshy,
Danli Wu,
Xueyou Hu,
Rajeev B. Tajhya,
Redwan Huq,
Fatima S. Khan,
Michael W. Pennington,
Heike Wulff,
Patricia Yotnda,
Christine Beeton

Published: October 11, 2013
https://doi.org/10.1371/journal.pone.0076740

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NK cells
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Cell degranulation
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Potassium channels
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T cells
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