A Remote Palm Domain Residue of RB69 DNA Polymerase Is Critical for Enzyme Activity and Influences the Conformation of the Active Site

Open Access

Peer-reviewed

Research Article

Agata Jacewicz,

Affiliation Department of Molecular Biology, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
⨯
Anna Trzemecka,

Affiliation Department of Molecular Biology, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
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Kip E. Guja,

Affiliation Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York, United States of America
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Danuta Plochocka,

Affiliation Department of Bioinformatics, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
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Elena Yakubovskaya,

Affiliation Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York, United States of America
⨯
Anna Bebenek ,

Contributed equally to this work with: Anna Bebenek, Miguel Garcia-Diaz

* E-mail: aniab@ibb.waw.pl (AB); miguel.garcia-diaz@stonybrook.edu (MGD)

Affiliation Department of Molecular Biology, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
⨯
Miguel Garcia-Diaz

Contributed equally to this work with: Anna Bebenek, Miguel Garcia-Diaz

* E-mail: aniab@ibb.waw.pl (AB); miguel.garcia-diaz@stonybrook.edu (MGD)

Affiliation Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York, United States of America
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Crystal structure
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Polymerases
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Nucleotides
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Bacteriophages
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DNA replication
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DNA polymerase
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DNA synthesis
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Enzyme structure
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