Directed Evolution of Aminoglycoside Phosphotransferase (3′) Type IIIa Variants That Inactivate Amikacin but Impose Significant Fitness Costs

Open Access

Peer-reviewed

Research Article

Joseph R. Kramer,

Affiliation Emory University School of Medicine, Department of Biochemistry, Rollins Research Center, Atlanta, Georgia, United States of America
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Ichiro Matsumura

* E-mail: imatsum@emory.edu

Affiliation Emory University School of Medicine, Department of Biochemistry, Rollins Research Center, Atlanta, Georgia, United States of America
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Enzymes
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Mutation
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Polymerase chain reaction
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Cloning
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Directed evolution
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Point mutation
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