Panobinostat Synergistically Enhances the Cytotoxic Effects of Cisplatin, Doxorubicin or Etoposide on High-Risk Neuroblastoma Cells

Guan Wang; Holly Edwards; J. Timothy Caldwell; Steven A. Buck; William Y. Qing; Jeffrey W. Taub; Yubin Ge; Zhihong Wang

doi:10.1371/journal.pone.0076662

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Peer-reviewed

Research Article

Panobinostat Synergistically Enhances the Cytotoxic Effects of Cisplatin, Doxorubicin or Etoposide on High-Risk Neuroblastoma Cells

Guan Wang,

Affiliations Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, United States of America, College of Life Science, Jilin University, Changchun, China
⨯
Holly Edwards,

Affiliations Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
J. Timothy Caldwell,

Affiliations MD/PhD Program, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Cancer Biology Program, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Steven A. Buck,

Affiliation Division of Pediatric Hematology/Oncology, Children's Hospital of Michigan, Detroit, Michigan, United States of America
⨯
William Y. Qing,

Affiliations Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Jeffrey W. Taub,

Affiliations Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Division of Pediatric Hematology/Oncology, Children's Hospital of Michigan, Detroit, Michigan, United States of America
⨯
Yubin Ge ,

* E-mail: Jwang2@med.wayne.edu (ZW); gey@karmanos.org (YG)

Affiliations College of Life Science, Jilin University, Changchun, China, Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Zhihong Wang

* E-mail: Jwang2@med.wayne.edu (ZW); gey@karmanos.org (YG)

Affiliations Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Division of Pediatric Hematology/Oncology, Children's Hospital of Michigan, Detroit, Michigan, United States of America
⨯

Panobinostat Synergistically Enhances the Cytotoxic Effects of Cisplatin, Doxorubicin or Etoposide on High-Risk Neuroblastoma Cells

Guan Wang,
Holly Edwards,
J. Timothy Caldwell,
Steven A. Buck,
William Y. Qing,
Jeffrey W. Taub,
Yubin Ge,
Zhihong Wang

Published: September 30, 2013
https://doi.org/10.1371/journal.pone.0076662

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