TGF-β1 Downregulates COX-2 Expression Leading to Decrease of PGE2 Production in Human Lung Cancer A549 Cells, Which Is Involved in Fibrotic Response to TGF-β1

Open Access

Peer-reviewed

Research Article

Erina Takai,

Affiliation Department of Radiation Biosciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda-shi, Chiba, Japan
⨯
Mitsutoshi Tsukimoto ,

* E-mail: tsukim@rs.noda.tus.ac.jp

Affiliation Department of Radiation Biosciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda-shi, Chiba, Japan
⨯
Shuji Kojima

Affiliation Department of Radiation Biosciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda-shi, Chiba, Japan
⨯

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Lung and intrathoracic tumors
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COX-2 inhibitors
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Cancer treatment
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Non-small cell lung cancer
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Messenger RNA
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Actins
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Fibrosis
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Gene expression
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