DNA Methylation Mediates Persistent Epileptiform Activity In Vitro and In Vivo

Ziv M. Machnes; Tony C. T. Huang; Philip K. Y. Chang; Raminder Gill; Nicholas Reist; Gabriella Dezsi; Ezgi Ozturk; Francois Charron; Terence J. O’Brien; Nigel C. Jones; R. Anne McKinney; Moshe Szyf

doi:10.1371/journal.pone.0076299

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Open Access

Peer-reviewed

Research Article

DNA Methylation Mediates Persistent Epileptiform Activity In Vitro and In Vivo

Ziv M. Machnes,

Affiliation Department of Pharmacology and Therapeutics McGill University, McGill University, Montreal, Quebec, Canada
⨯
Tony C. T. Huang,

Affiliation Department of Pharmacology and Therapeutics McGill University, McGill University, Montreal, Quebec, Canada
⨯
Philip K. Y. Chang,

Affiliation Department of Pharmacology and Therapeutics McGill University, McGill University, Montreal, Quebec, Canada
⨯
Raminder Gill,

Affiliation Department of Pharmacology and Therapeutics McGill University, McGill University, Montreal, Quebec, Canada
⨯
Nicholas Reist,

Affiliation Department of Pharmacology and Therapeutics McGill University, McGill University, Montreal, Quebec, Canada
⨯
Gabriella Dezsi,

Affiliation Department of Medicine (Royal Melbourne Hospital), Melbourne Brain Centre, University of Melbourne, Parkville, Victoria, Australia
⨯
Ezgi Ozturk,

Affiliation Department of Medicine (Royal Melbourne Hospital), Melbourne Brain Centre, University of Melbourne, Parkville, Victoria, Australia
⨯
Francois Charron,

Affiliation Department of Pharmacology and Therapeutics McGill University, McGill University, Montreal, Quebec, Canada
⨯
Terence J. O’Brien,

Affiliation Department of Medicine (Royal Melbourne Hospital), Melbourne Brain Centre, University of Melbourne, Parkville, Victoria, Australia
⨯
Nigel C. Jones,

Affiliation Department of Medicine (Royal Melbourne Hospital), Melbourne Brain Centre, University of Melbourne, Parkville, Victoria, Australia
⨯
R. Anne McKinney ,

Contributed equally to this work with: R. Anne McKinney, Moshe Szyf

* E-mail: moshe.szyf@mcgill.ca (MS); anne.mckinney@mcgill.ca (RAM)

Affiliation Department of Pharmacology and Therapeutics McGill University, McGill University, Montreal, Quebec, Canada
⨯
Moshe Szyf

Contributed equally to this work with: R. Anne McKinney, Moshe Szyf

* E-mail: moshe.szyf@mcgill.ca (MS); anne.mckinney@mcgill.ca (RAM)

Affiliation Department of Pharmacology and Therapeutics McGill University, McGill University, Montreal, Quebec, Canada
⨯

DNA Methylation Mediates Persistent Epileptiform Activity In Vitro and In Vivo

Ziv M. Machnes,
Tony C. T. Huang,
Philip K. Y. Chang,
Raminder Gill,
Nicholas Reist,
Gabriella Dezsi,
Ezgi Ozturk,
Francois Charron,
Terence J. O’Brien,
Nigel C. Jones

Published: October 2, 2013
https://doi.org/10.1371/journal.pone.0076299

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Hippocampus
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Epilepsy
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Polymerase chain reaction
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Gene expression
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Plasmid construction
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