The Heme Oxygenase-1 Inducer THI-56 Negatively Regulates iNOS Expression and HMGB1 Release in LPS-Activated RAW 264.7 Cells and CLP-Induced Septic Mice

Eun Jung Park; Hwa Jin Jang; Konstantin Tsoyi; Young Min Kim; Sang Won Park; Hye Jung Kim; Jae Heun Lee; Ki Churl Chang

doi:10.1371/journal.pone.0076293

Loading metrics

Open Access

Peer-reviewed

Research Article

The Heme Oxygenase-1 Inducer THI-56 Negatively Regulates iNOS Expression and HMGB1 Release in LPS-Activated RAW 264.7 Cells and CLP-Induced Septic Mice

Eun Jung Park ,

Contributed equally to this work with: Eun Jung Park, Hwa Jin Jang, Konstantin Tsoyi

Affiliation Department of Pharmacology, School of Medicine Gyeongsang National University and Institute of Health Sciences, Jinju, Korea
⨯
Hwa Jin Jang ,

Contributed equally to this work with: Eun Jung Park, Hwa Jin Jang, Konstantin Tsoyi

Affiliation Department of Pharmacology, School of Medicine Gyeongsang National University and Institute of Health Sciences, Jinju, Korea
⨯
Konstantin Tsoyi ,

Contributed equally to this work with: Eun Jung Park, Hwa Jin Jang, Konstantin Tsoyi

Affiliation Department of Pharmacology, School of Medicine Gyeongsang National University and Institute of Health Sciences, Jinju, Korea
⨯
Young Min Kim,

Affiliation Department of Pharmacology, School of Medicine Gyeongsang National University and Institute of Health Sciences, Jinju, Korea
⨯
Sang Won Park,

Affiliation Department of Pharmacology, School of Medicine Gyeongsang National University and Institute of Health Sciences, Jinju, Korea
⨯
Hye Jung Kim,

Affiliation Department of Pharmacology, School of Medicine Gyeongsang National University and Institute of Health Sciences, Jinju, Korea
⨯
Jae Heun Lee,

Affiliation Department of Pharmacology, School of Medicine Gyeongsang National University and Institute of Health Sciences, Jinju, Korea
⨯
Ki Churl Chang

* E-mail: kcchang@gnu.kr

Affiliation Department of Pharmacology, School of Medicine Gyeongsang National University and Institute of Health Sciences, Jinju, Korea
⨯

The Heme Oxygenase-1 Inducer THI-56 Negatively Regulates iNOS Expression and HMGB1 Release in LPS-Activated RAW 264.7 Cells and CLP-Induced Septic Mice

Eun Jung Park,
Hwa Jin Jang,
Konstantin Tsoyi,
Young Min Kim,
Sang Won Park,
Hye Jung Kim,
Jae Heun Lee,
Ki Churl Chang

Published: October 3, 2013
https://doi.org/10.1371/journal.pone.0076293

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Sepsis
Is the Subject Area "Sepsis" applicable to this article?

Thanks for your feedback.
Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
Small interfering RNA
Is the Subject Area "Small interfering RNA" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Endotoxemia
Is the Subject Area "Endotoxemia" applicable to this article?

Thanks for your feedback.
Blood
Is the Subject Area "Blood" applicable to this article?

Thanks for your feedback.