The Presence of CXCR4-Using HIV-1 Prior to Start of Antiretroviral Therapy Is an Independent Predictor of Delayed Viral Suppression

Esther F. Gijsbers; Ard van Sighem; Agnes M. Harskamp; Matthijs R. A. Welkers; Frank de Wolf; Kees Brinkman; Jan M. Prins; Hanneke Schuitemaker; Angélique B. van ’t Wout; Neeltje A. Kootstra

doi:10.1371/journal.pone.0076255

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Open Access

Peer-reviewed

Research Article

The Presence of CXCR4-Using HIV-1 Prior to Start of Antiretroviral Therapy Is an Independent Predictor of Delayed Viral Suppression

Esther F. Gijsbers,

Affiliation Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory and Center for Infectious Diseases and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Ard van Sighem,

Affiliation Stichting HIV Monitoring, Amsterdam, The Netherlands
⨯
Agnes M. Harskamp,

Affiliation Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory and Center for Infectious Diseases and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Matthijs R. A. Welkers,

Current address: Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands

Affiliation Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory and Center for Infectious Diseases and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Frank de Wolf,

Current address: Crucell Holland BV, Leiden, the Netherlands

Affiliations Stichting HIV Monitoring, Amsterdam, The Netherlands, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom
⨯
Kees Brinkman,

Affiliation Department of Internal Medicine, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
⨯
Jan M. Prins,

Affiliation Department of Internal Medicine, Center for Infectious Diseases and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Hanneke Schuitemaker,

Current address: Crucell Holland BV, Leiden, the Netherlands

Affiliation Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory and Center for Infectious Diseases and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Angélique B. van ’t Wout,

Current address: Crucell Holland BV, Leiden, the Netherlands

Affiliation Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory and Center for Infectious Diseases and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Neeltje A. Kootstra

* E-mail: N.A.Kootstra@amc.uva.nl

Affiliation Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory and Center for Infectious Diseases and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯

The Presence of CXCR4-Using HIV-1 Prior to Start of Antiretroviral Therapy Is an Independent Predictor of Delayed Viral Suppression

Esther F. Gijsbers,
Ard van Sighem,
Agnes M. Harskamp,
Matthijs R. A. Welkers,
Frank de Wolf,
Kees Brinkman,
Jan M. Prins,
Hanneke Schuitemaker,
Angélique B. van ’t Wout,
Neeltje A. Kootstra

Published: October 1, 2013
https://doi.org/10.1371/journal.pone.0076255

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