Zfat-Deficiency Results in a Loss of CD3ζ Phosphorylation with Dysregulation of ERK and Egr Activities Leading to Impaired Positive Selection

• Masahiro Ogawa ,

  Contributed equally to this work with: Masahiro Ogawa, Tadashi Okamura

  Affiliations Department of Cell Biology, Faculty of Medicine, Fukuoka University, Jonan-ku, Fukuoka, Japan, Central Research Institute for Advanced Molecular Medicine, Fukuoka University, Jonan-ku, Fukuoka, Japan

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• Tadashi Okamura ,

  Contributed equally to this work with: Masahiro Ogawa, Tadashi Okamura

  Affiliation Division of Animal Models, Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

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• Shuhei Ishikura,

  Affiliations Department of Cell Biology, Faculty of Medicine, Fukuoka University, Jonan-ku, Fukuoka, Japan, Central Research Institute for Advanced Molecular Medicine, Fukuoka University, Jonan-ku, Fukuoka, Japan

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• Keiko Doi,

  Affiliations Department of Cell Biology, Faculty of Medicine, Fukuoka University, Jonan-ku, Fukuoka, Japan, Central Research Institute for Advanced Molecular Medicine, Fukuoka University, Jonan-ku, Fukuoka, Japan

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• Hiroshi Matsuzaki,

  Affiliation Department of Cell Biology, Faculty of Medicine, Fukuoka University, Jonan-ku, Fukuoka, Japan

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• Yoko Tanaka,

  Affiliation Department of Cell Biology, Faculty of Medicine, Fukuoka University, Jonan-ku, Fukuoka, Japan

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• Takeharu Ota,

  Affiliations Department of Cell Biology, Faculty of Medicine, Fukuoka University, Jonan-ku, Fukuoka, Japan, Central Research Institute for Advanced Molecular Medicine, Fukuoka University, Jonan-ku, Fukuoka, Japan

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• Kunihiro Hayakawa,

  Affiliation Department of Immunology and Pathology, National Institute for Global Health and Medicine, Chiba, Japan

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• Harumi Suzuki,

  Affiliation Department of Immunology and Pathology, National Institute for Global Health and Medicine, Chiba, Japan

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• Toshiyuki Tsunoda,

  Affiliations Department of Cell Biology, Faculty of Medicine, Fukuoka University, Jonan-ku, Fukuoka, Japan, Central Research Institute for Advanced Molecular Medicine, Fukuoka University, Jonan-ku, Fukuoka, Japan

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• Takehiko Sasazuki,

  Affiliation Institute for Advanced Study, Kyushu University, Fukuoka, Japan

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• Senji Shirasawa

  * E-mail: sshirasa@fukuoka-u.ac.jp

  Affiliations Department of Cell Biology, Faculty of Medicine, Fukuoka University, Jonan-ku, Fukuoka, Japan, Central Research Institute for Advanced Molecular Medicine, Fukuoka University, Jonan-ku, Fukuoka, Japan

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