Structural Insights into Neutrophilic Migration Revealed by the Crystal Structure of the Chemokine Receptor CXCR2 in Complex with the First PDZ Domain of NHERF1

Guorong Lu; Yanning Wu; Yuanyuan Jiang; Shuo Wang; Yuning Hou; Xiaoqing Guan; Joseph Brunzelle; Nualpun Sirinupong; Shijie Sheng; Chunying Li; Zhe Yang

doi:10.1371/journal.pone.0076219

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Open Access

Peer-reviewed

Research Article

Structural Insights into Neutrophilic Migration Revealed by the Crystal Structure of the Chemokine Receptor CXCR2 in Complex with the First PDZ Domain of NHERF1

Guorong Lu ,

Contributed equally to this work with: Guorong Lu, Yanning Wu, Yuanyuan Jiang

Affiliation Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Yanning Wu ,

Contributed equally to this work with: Guorong Lu, Yanning Wu, Yuanyuan Jiang

Affiliation Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Yuanyuan Jiang ,

Contributed equally to this work with: Guorong Lu, Yanning Wu, Yuanyuan Jiang

Affiliation Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Shuo Wang,

Affiliation Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Yuning Hou,

Affiliation Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Xiaoqing Guan,

Affiliation Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Joseph Brunzelle,

Affiliation Advance Photon Source, Argonne National Laboratory, Argonne, Illinois, United States of America
⨯
Nualpun Sirinupong,

Affiliation Nutraceuticals and Functional Food Research and Development Center, Prince of Songkla University, Hat-Yai, Songkhla, Thailand
⨯
Shijie Sheng,

Affiliation Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Chunying Li ,

* E-mail: zyang@med.wayne.edu (ZY); cl@med.wayne.edu (CL)

Affiliation Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Zhe Yang

* E-mail: zyang@med.wayne.edu (ZY); cl@med.wayne.edu (CL)

Affiliation Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯

Structural Insights into Neutrophilic Migration Revealed by the Crystal Structure of the Chemokine Receptor CXCR2 in Complex with the First PDZ Domain of NHERF1

Guorong Lu,
Yanning Wu,
Yuanyuan Jiang,
Shuo Wang,
Yuning Hou,
Xiaoqing Guan,
Joseph Brunzelle,
Nualpun Sirinupong,
Shijie Sheng,
Chunying Li

Published: October 2, 2013
https://doi.org/10.1371/journal.pone.0076219

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Crystal structure
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Hydrogen bonding
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Neutrophils
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Chemokines
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