Overnight Resting of PBMC Changes Functional Signatures of Antigen Specific T- Cell Responses: Impact for Immune Monitoring within Clinical Trials

Sarah Kutscher; Claudia J. Dembek; Simone Deckert; Carolina Russo; Nina Körber; Johannes R. Bogner; Fabian Geisler; Andreas Umgelter; Michael Neuenhahn; Julia Albrecht; Antonio Cosma; Ulrike Protzer; Tanja Bauer

doi:10.1371/journal.pone.0076215

Loading metrics

Open Access

Peer-reviewed

Research Article

Overnight Resting of PBMC Changes Functional Signatures of Antigen Specific T- Cell Responses: Impact for Immune Monitoring within Clinical Trials

Sarah Kutscher,

Current address: immatics biotechnologies GmbH, Tübingen, Germany

Affiliations Institute of Virology, Technische Universität München/Helmholtz Zentrum München, Munich, Germany, Cooperation Group ‘Immune Monitoring’, Helmholtz Zentrum München, Munich, Germany
⨯
Claudia J. Dembek,

Affiliations Institute of Virology, Technische Universität München/Helmholtz Zentrum München, Munich, Germany, Cooperation Group ‘Immune Monitoring’, Helmholtz Zentrum München, Munich, Germany, German Center for Infection Research (DZIF), Munich, Germany
⨯
Simone Deckert,

Affiliations Institute of Virology, Technische Universität München/Helmholtz Zentrum München, Munich, Germany, Cooperation Group ‘Immune Monitoring’, Helmholtz Zentrum München, Munich, Germany
⨯
Carolina Russo,

Affiliation Institute of Virology, Technische Universität München/Helmholtz Zentrum München, Munich, Germany
⨯
Nina Körber,

Affiliation Institute of Virology, Technische Universität München/Helmholtz Zentrum München, Munich, Germany
⨯
Johannes R. Bogner,

Affiliation Department of Infectious Diseases/Med. Klinik und Poliklinik, University Hospital of Munich/Ludwig Maximilians Universität, Munich, Germany
⨯
Fabian Geisler,

Affiliation Department of Internal Medicine II, Klinikum rechts der Isar/Technische Universität München, Munich, Germany
⨯
Andreas Umgelter,

Affiliation Department of Internal Medicine II, Klinikum rechts der Isar/Technische Universität München, Munich, Germany
⨯
Michael Neuenhahn,

Affiliations Cooperation Group ‘Immune Monitoring’, Helmholtz Zentrum München, Munich, Germany, Institute of Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany
⨯
Julia Albrecht,

Affiliations Cooperation Group ‘Immune Monitoring’, Helmholtz Zentrum München, Munich, Germany, Institute of Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany
⨯
Antonio Cosma,

Affiliation Division of Immuno-Virology, CEA, Paris, France
⨯
Ulrike Protzer,

Affiliations Institute of Virology, Technische Universität München/Helmholtz Zentrum München, Munich, Germany, Cooperation Group ‘Immune Monitoring’, Helmholtz Zentrum München, Munich, Germany, German Center for Infection Research (DZIF), Munich, Germany
⨯
Tanja Bauer

* E-mail: tanja.bauer@helmholtz-muenchen.de

Affiliations Institute of Virology, Technische Universität München/Helmholtz Zentrum München, Munich, Germany, Cooperation Group ‘Immune Monitoring’, Helmholtz Zentrum München, Munich, Germany
⨯

Overnight Resting of PBMC Changes Functional Signatures of Antigen Specific T- Cell Responses: Impact for Immune Monitoring within Clinical Trials

Sarah Kutscher,
Claudia J. Dembek,
Simone Deckert,
Carolina Russo,
Nina Körber,
Johannes R. Bogner,
Fabian Geisler,
Andreas Umgelter,
Michael Neuenhahn,
Julia Albrecht

Published: October 11, 2013
https://doi.org/10.1371/journal.pone.0076215

Reader Comments (1)

Post a new comment on this article

0 Responses

31 Aug 2014
18:54 GMT
Most Recent

Overnight resting allows lymphocyte recovery from preparative stress Posted by forsdyke on 31 Aug 2014 at 18:54 GMT

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.
Cytotoxic T cells
Is the Subject Area "Cytotoxic T cells" applicable to this article?

Thanks for your feedback.
HIV
Is the Subject Area "HIV" applicable to this article?

Thanks for your feedback.
Cell staining
Is the Subject Area "Cell staining" applicable to this article?

Thanks for your feedback.
Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.
Blood
Is the Subject Area "Blood" applicable to this article?

Thanks for your feedback.
T helper cells
Is the Subject Area "T helper cells" applicable to this article?

Thanks for your feedback.
Antigen-presenting cells
Is the Subject Area "Antigen-presenting cells" applicable to this article?

Thanks for your feedback.