Pseudomonas putida AlkA and AlkB Proteins Comprise Different Defense Systems for the Repair of Alkylation Damage to DNA – In Vivo, In Vitro, and In Silico Studies

Damian Mielecki; Signe Saumaa; Michał Wrzesiński; Agnieszka M. Maciejewska; Karolina Żuchniewicz; Anna Sikora; Jan Piwowarski; Jadwiga Nieminuszczy; Maia Kivisaar; Elżbieta Grzesiuk

doi:10.1371/journal.pone.0076198

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Peer-reviewed

Research Article

Pseudomonas putida AlkA and AlkB Proteins Comprise Different Defense Systems for the Repair of Alkylation Damage to DNA – In Vivo, In Vitro, and In Silico Studies

Damian Mielecki,

Affiliation Department of Molecular Biology, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
⨯
Signe Saumaa,

Affiliation Department of Genetics, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
⨯
Michał Wrzesiński,

Affiliation Department of Molecular Biology, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
⨯
Agnieszka M. Maciejewska,

Affiliation Department of Molecular Biology, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
⨯
Karolina Żuchniewicz,

Affiliation Department of Molecular Biology, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
⨯
Anna Sikora,

Affiliation Department of Molecular Biology, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
⨯
Jan Piwowarski,

Affiliation Department of Molecular Biology, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
⨯
Jadwiga Nieminuszczy,

Affiliation Department of Molecular Biology, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
⨯
Maia Kivisaar ,

* E-mail: elag@ibb.waw.pl (EG); maia.kivisaar@ut.ee (MK)

Affiliation Department of Genetics, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
⨯
Elżbieta Grzesiuk

* E-mail: elag@ibb.waw.pl (EG); maia.kivisaar@ut.ee (MK)

Affiliation Department of Molecular Biology, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
⨯

Pseudomonas putida AlkA and AlkB Proteins Comprise Different Defense Systems for the Repair of Alkylation Damage to DNA – In Vivo, In Vitro, and In Silico Studies

Damian Mielecki,
Signe Saumaa,
Michał Wrzesiński,
Agnieszka M. Maciejewska,
Karolina Żuchniewicz,
Anna Sikora,
Jan Piwowarski,
Jadwiga Nieminuszczy,
Maia Kivisaar,
Elżbieta Grzesiuk

Published: October 2, 2013
https://doi.org/10.1371/journal.pone.0076198

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Pseudomonas putida
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DNA repair
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DNA
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DNA damage
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