IL-27 Enhances the Expression of TRAIL and TLR3 in Human Melanomas and Inhibits Their Tumor Growth in Cooperation with a TLR3 Agonist Poly(I:C) Partly in a TRAIL-Dependent Manner

• Yukino Chiba ,

  Contributed equally to this work with: Yukino Chiba, Izuru Mizoguchi

  Affiliation Department of Immunoregulation, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan

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• Izuru Mizoguchi ,

  Contributed equally to this work with: Yukino Chiba, Izuru Mizoguchi

  Affiliation Department of Immunoregulation, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan

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• Kana Mitobe,

  Affiliation Department of Immunoregulation, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan

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• Kaname Higuchi,

  Affiliations Department of Immunoregulation, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan, Department of Immunology, Tokyo Medical University, Tokyo, Japan

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• Hiroshi Nagai,

  Affiliation Division of Dermatology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan

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• Chikako Nishigori,

  Affiliation Division of Dermatology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan

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• Junichiro Mizuguchi,

  Affiliation Department of Immunology, Tokyo Medical University, Tokyo, Japan

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• Takayuki Yoshimoto

  * E-mail: yoshimot@tokyo-med.ac.jp

  Affiliation Department of Immunoregulation, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan

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