CD146+ Human Umbilical Cord Perivascular Cells Maintain Stemness under Hypoxia and as a Cell Source for Skeletal Regeneration

Wing Pui Tsang; Yinglan Shu; Po Lam Kwok; Fengjie Zhang; Kenneth Ka Ho Lee; Mei Kuen Tang; Gang Li; Kai Ming Chan; Wai-Yee Chan; Chao Wan

doi:10.1371/journal.pone.0076153

Loading metrics

Open Access

Peer-reviewed

Research Article

CD146⁺ Human Umbilical Cord Perivascular Cells Maintain Stemness under Hypoxia and as a Cell Source for Skeletal Regeneration

Wing Pui Tsang,

Affiliations Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China, School of Biomedical Sciences Core Laboratory, The Chinese University of Hong Kong Shenzhen Research Institute, Shenzhen, China
⨯
Yinglan Shu,

Affiliation Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
⨯
Po Lam Kwok,

Affiliation Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
⨯
Fengjie Zhang,

Affiliations Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China, School of Biomedical Sciences Core Laboratory, The Chinese University of Hong Kong Shenzhen Research Institute, Shenzhen, China
⨯
Kenneth Ka Ho Lee,

Affiliations Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China, School of Biomedical Sciences Core Laboratory, The Chinese University of Hong Kong Shenzhen Research Institute, Shenzhen, China
⨯
Mei Kuen Tang,

Affiliation Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
⨯
Gang Li,

Affiliations Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China
⨯
Kai Ming Chan,

Affiliation Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China
⨯
Wai-Yee Chan,

Affiliations Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China, School of Biomedical Sciences Core Laboratory, The Chinese University of Hong Kong Shenzhen Research Institute, Shenzhen, China
⨯
Chao Wan

* E-mail: cwan@cuhk.edu.hk

Affiliations Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China, School of Biomedical Sciences Core Laboratory, The Chinese University of Hong Kong Shenzhen Research Institute, Shenzhen, China
⨯

CD146⁺ Human Umbilical Cord Perivascular Cells Maintain Stemness under Hypoxia and as a Cell Source for Skeletal Regeneration

Wing Pui Tsang,
Yinglan Shu,
Po Lam Kwok,
Fengjie Zhang,
Kenneth Ka Ho Lee,
Mei Kuen Tang,
Gang Li,
Kai Ming Chan,
Wai-Yee Chan,
Chao Wan

Published: October 18, 2013
https://doi.org/10.1371/journal.pone.0076153

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Hypoxia
Is the Subject Area "Hypoxia" applicable to this article?

Thanks for your feedback.
Cell differentiation
Is the Subject Area "Cell differentiation" applicable to this article?

Thanks for your feedback.
Transcription factors
Is the Subject Area "Transcription factors" applicable to this article?

Thanks for your feedback.
Oxygen
Is the Subject Area "Oxygen" applicable to this article?

Thanks for your feedback.
Polymerase chain reaction
Is the Subject Area "Polymerase chain reaction" applicable to this article?

Thanks for your feedback.
Stem cells
Is the Subject Area "Stem cells" applicable to this article?

Thanks for your feedback.
Adipocyte differentiation
Is the Subject Area "Adipocyte differentiation" applicable to this article?

Thanks for your feedback.
Cell staining
Is the Subject Area "Cell staining" applicable to this article?

Thanks for your feedback.