Loss of DAP12 and FcRγ Drives Exaggerated IL-12 Production and CD8+ T Cell Response by CCR2+ Mo-DCs

Grzegorz B. Gmyrek; Holly M. Akilesh; Daniel B. Graham; Anja Fuchs; Lihua Yang; Mark J. Miller; Gabriel J. Sandoval; Kathleen C. F. Sheehan; Robert D. Schreiber; Michael S. Diamond; Wojciech Swat

doi:10.1371/journal.pone.0076145

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Peer-reviewed

Research Article

Loss of DAP12 and FcRγ Drives Exaggerated IL-12 Production and CD8⁺ T Cell Response by CCR2⁺ Mo-DCs

Grzegorz B. Gmyrek,

Affiliation Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Holly M. Akilesh,

Affiliation Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Daniel B. Graham,

Affiliation Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Anja Fuchs,

Affiliation Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Lihua Yang,

Affiliation Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Mark J. Miller,

Affiliations Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Gabriel J. Sandoval,

Affiliation Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Kathleen C. F. Sheehan,

Affiliation Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Robert D. Schreiber,

Affiliation Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Michael S. Diamond,

Affiliations Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Wojciech Swat

* E-mail: swat@wustl.edu

Affiliation Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯

Loss of DAP12 and FcRγ Drives Exaggerated IL-12 Production and CD8⁺ T Cell Response by CCR2⁺ Mo-DCs

Grzegorz B. Gmyrek,
Holly M. Akilesh,
Daniel B. Graham,
Anja Fuchs,
Lihua Yang,
Mark J. Miller,
Gabriel J. Sandoval,
Kathleen C. F. Sheehan,
Robert D. Schreiber,
Michael S. Diamond

Published: October 14, 2013
https://doi.org/10.1371/journal.pone.0076145

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