How Changes in Extracellular Matrix Mechanics and Gene Expression Variability Might Combine to Drive Cancer Progression

• Justin Werfel ,

  Contributed equally to this work with: Justin Werfel, Silva Krause

  Affiliation Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, United States of America

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• Silva Krause ,

  Contributed equally to this work with: Justin Werfel, Silva Krause

  Affiliation Vascular Biology Program and Department of Surgery, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Ashley G. Bischof,

  Affiliations Vascular Biology Program and Department of Surgery, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Graduate Program in Biophysics, Harvard University, Cambridge, Massachusetts, United States of America

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• Robert J. Mannix,

  Affiliation Vascular Biology Program and Department of Surgery, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Heather Tobin,

  Affiliation Vascular Biology Program and Department of Surgery, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Yaneer Bar-Yam,

  Affiliation New England Complex Systems Institute, Cambridge, Massachusetts, United States of America

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• Robert M. Bellin,

  Affiliation Department of Biology, College of the Holy Cross, Worcester, Massachusetts, United States of America

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• Donald E. Ingber

  * E-mail: don.ingber@wyss.harvard.edu

  Affiliations Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, United States of America, Vascular Biology Program and Department of Surgery, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Harvard School of Engineering and Applied Sciences, Cambridge, Massachusetts, United States of America

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