Identification of Mur34 as the Novel Negative Regulator Responsible for the Biosynthesis of Muraymycin in Streptomyces sp. NRRL30471

Dongmei Xu; Guang Liu; Lin Cheng; Xinhua Lu; Wenqing Chen; Zixin Deng

doi:10.1371/journal.pone.0076068

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Peer-reviewed

Research Article

Identification of Mur34 as the Novel Negative Regulator Responsible for the Biosynthesis of Muraymycin in Streptomyces sp. NRRL30471

Dongmei Xu,

Affiliations State Key Laboratory of Microbial Metabolism, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China, NCPC New Drug Research and Development Co., Ltd, North China Pharmaceutical Group Corporation, Shijiazhuang, China
⨯
Guang Liu,

Affiliation State Key Laboratory of Microbial Metabolism, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China
⨯
Lin Cheng,

Affiliation Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, and Wuhan University School of Pharmaceutical Sciences, Wuhan, China
⨯
Xinhua Lu,

Affiliation NCPC New Drug Research and Development Co., Ltd, North China Pharmaceutical Group Corporation, Shijiazhuang, China
⨯
Wenqing Chen ,

* E-mail: zxdeng@sjtu.edu.cn (ZD); wenqingchen2010@gmail.com (WC)

Affiliations State Key Laboratory of Microbial Metabolism, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, and Wuhan University School of Pharmaceutical Sciences, Wuhan, China
⨯
Zixin Deng

* E-mail: zxdeng@sjtu.edu.cn (ZD); wenqingchen2010@gmail.com (WC)

Affiliations State Key Laboratory of Microbial Metabolism, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, and Wuhan University School of Pharmaceutical Sciences, Wuhan, China
⨯

Identification of Mur34 as the Novel Negative Regulator Responsible for the Biosynthesis of Muraymycin in Streptomyces sp. NRRL30471

Dongmei Xu,
Guang Liu,
Lin Cheng,
Xinhua Lu,
Wenqing Chen,
Zixin Deng

Published: October 15, 2013
https://doi.org/10.1371/journal.pone.0076068

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Polymerase chain reaction
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Biosynthesis
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Streptomyces
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