Anti-HIV Activity of Human Defensin 5 in Primary CD4+ T Cells under Serum-Deprived Conditions Is a Consequence of Defensin-Mediated Cytotoxicity

Jian Ding; Carley Tasker; Kimyata Valere; Tiina Sihvonen; Dante B. Descalzi-Montoya; Wuyuan Lu; Theresa L. Chang

doi:10.1371/journal.pone.0076038

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Peer-reviewed

Research Article

Anti-HIV Activity of Human Defensin 5 in Primary CD4+ T Cells under Serum-Deprived Conditions Is a Consequence of Defensin-Mediated Cytotoxicity

Jian Ding,

Affiliation Public Health Research Institute, Rutgers Biomedical and Health Sciences-New Jersey Medical School, Newark, New Jersey, United States of America
⨯
Carley Tasker,

Affiliations Department of Microbiology and Molecular Genetics, Rutgers Biomedical and Health Sciences-New Jersey Medical School, Newark, New Jersey, United States of America, Graduate School of Biomedical Sciences, Rutgers Biomedical and Health Sciences-New Jersey Medical School, Newark, New Jersey, United States of America
⨯
Kimyata Valere,

Affiliations Department of Microbiology and Molecular Genetics, Rutgers Biomedical and Health Sciences-New Jersey Medical School, Newark, New Jersey, United States of America, Graduate School of Biomedical Sciences, Rutgers Biomedical and Health Sciences-New Jersey Medical School, Newark, New Jersey, United States of America
⨯
Tiina Sihvonen,

Affiliation Public Health Research Institute, Rutgers Biomedical and Health Sciences-New Jersey Medical School, Newark, New Jersey, United States of America
⨯
Dante B. Descalzi-Montoya,

Affiliations Department of Pathology and Laboratory Medicine, Rutgers Biomedical and Health Sciences-New Jersey Medical School, Newark, New Jersey, United States of America, Graduate School of Biomedical Sciences, Rutgers Biomedical and Health Sciences-New Jersey Medical School, Newark, New Jersey, United States of America
⨯
Wuyuan Lu,

Affiliation Institute of Human Virology and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
⨯
Theresa L. Chang

* E-mail: changth@umdnj.edu

Affiliations Public Health Research Institute, Rutgers Biomedical and Health Sciences-New Jersey Medical School, Newark, New Jersey, United States of America, Department of Microbiology and Molecular Genetics, Rutgers Biomedical and Health Sciences-New Jersey Medical School, Newark, New Jersey, United States of America
⨯

Anti-HIV Activity of Human Defensin 5 in Primary CD4+ T Cells under Serum-Deprived Conditions Is a Consequence of Defensin-Mediated Cytotoxicity

Jian Ding,
Carley Tasker,
Kimyata Valere,
Tiina Sihvonen,
Dante B. Descalzi-Montoya,
Wuyuan Lu,
Theresa L. Chang

Published: September 25, 2013
https://doi.org/10.1371/journal.pone.0076038

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