Gender-Specific Metabolomic Profiling of Obesity in Leptin-Deficient ob/ob Mice by 1H NMR Spectroscopy

Eun-Young Won; Mi-Kyung Yoon; Sang-Woo Kim; Youngae Jung; Hyun-Whee Bae; Daeyoup Lee; Sung Goo Park; Chul-Ho Lee; Geum-Sook Hwang; Seung-Wook Chi

doi:10.1371/journal.pone.0075998

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Open Access

Peer-reviewed

Research Article

Gender-Specific Metabolomic Profiling of Obesity in Leptin-Deficient ob/ob Mice by ¹H NMR Spectroscopy

Eun-Young Won ,

Contributed equally to this work with: Eun-Young Won, Mi-Kyung Yoon

Affiliations Medical Proteomics Research Center, KRIBB, Daejeon, Republic of Korea, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea
⨯
Mi-Kyung Yoon ,

Contributed equally to this work with: Eun-Young Won, Mi-Kyung Yoon

Affiliation Medical Proteomics Research Center, KRIBB, Daejeon, Republic of Korea
⨯
Sang-Woo Kim,

Affiliation Laboratory Animal Center, KRIBB, Daejeon, Republic of Korea
⨯
Youngae Jung,

Affiliation Integrated Metabolomics Research Group, Seoul Center, Korea Basic Science Institute, Seoul, Republic of Korea
⨯
Hyun-Whee Bae,

Affiliations Integrated Metabolomics Research Group, Seoul Center, Korea Basic Science Institute, Seoul, Republic of Korea, Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, Republic of Korea
⨯
Daeyoup Lee,

Affiliation Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea
⨯
Sung Goo Park,

Affiliation Medical Proteomics Research Center, KRIBB, Daejeon, Republic of Korea
⨯
Chul-Ho Lee ,

* E-mail: chullee@kribb.re.kr (CHL); gshwang@kbsi.re.kr (GSH); swchi@kribb.re.kr (SWC)

Affiliation Laboratory Animal Center, KRIBB, Daejeon, Republic of Korea
⨯
Geum-Sook Hwang ,

* E-mail: chullee@kribb.re.kr (CHL); gshwang@kbsi.re.kr (GSH); swchi@kribb.re.kr (SWC)

Affiliations Integrated Metabolomics Research Group, Seoul Center, Korea Basic Science Institute, Seoul, Republic of Korea, Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, Republic of Korea
⨯
Seung-Wook Chi

* E-mail: chullee@kribb.re.kr (CHL); gshwang@kbsi.re.kr (GSH); swchi@kribb.re.kr (SWC)

Affiliation Medical Proteomics Research Center, KRIBB, Daejeon, Republic of Korea
⨯

Gender-Specific Metabolomic Profiling of Obesity in Leptin-Deficient ob/ob Mice by ¹H NMR Spectroscopy

Eun-Young Won,
Mi-Kyung Yoon,
Sang-Woo Kim,
Youngae Jung,
Hyun-Whee Bae,
Daeyoup Lee,
Sung Goo Park,
Chul-Ho Lee,
Geum-Sook Hwang,
Seung-Wook Chi

Published: October 3, 2013
https://doi.org/10.1371/journal.pone.0075998

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