Specific mtDNA Mutations in Mouse Carcinoma Cells Suppress Their Tumor Formation via Activation of the Host Innate Immune System

Hirotake Imanishi; Gaku Takibuchi; Toshihiko Kobayashi; Kaori Ishikawa; Kazuto Nakada; Masayuki Mori; Yoshiaki Kikkawa; Keizo Takenaga; Noriko Toyama-Sorimachi; Jun-Ichi Hayashi

doi:10.1371/journal.pone.0075981

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Open Access

Peer-reviewed

Research Article

Specific mtDNA Mutations in Mouse Carcinoma Cells Suppress Their Tumor Formation via Activation of the Host Innate Immune System

Hirotake Imanishi ,

Contributed equally to this work with: Hirotake Imanishi, Gaku Takibuchi

Affiliations Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan, Japan Society for the Promotion of Science, Tokyo, Japan, Department of Molecular Immunology and Inflammation, National Center for Global Health and Medicine, Tokyo, Japan
⨯
Gaku Takibuchi ,

Contributed equally to this work with: Hirotake Imanishi, Gaku Takibuchi

Affiliation Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
⨯
Toshihiko Kobayashi,

Affiliation Department of Molecular Immunology and Inflammation, National Center for Global Health and Medicine, Tokyo, Japan
⨯
Kaori Ishikawa,

Affiliation Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
⨯
Kazuto Nakada,

Affiliations Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan, International Institute for Integrative Sleep Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
⨯
Masayuki Mori,

Affiliation Department of Aging Angiology, Research Center on Aging and Adaptation, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
⨯
Yoshiaki Kikkawa,

Affiliation Mammalian Genetics Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
⨯
Keizo Takenaga,

Affiliation Department of Life Science, Shimane University Faculty of Medicine, Izumo, Shimane, Japan
⨯
Noriko Toyama-Sorimachi,

Affiliation Department of Molecular Immunology and Inflammation, National Center for Global Health and Medicine, Tokyo, Japan
⨯
Jun-Ichi Hayashi

* E-mail: jih45@biol.tsukuba.ac.jp

Affiliations Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan, International Institute for Integrative Sleep Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
⨯

Specific mtDNA Mutations in Mouse Carcinoma Cells Suppress Their Tumor Formation via Activation of the Host Innate Immune System

Hirotake Imanishi,
Gaku Takibuchi,
Toshihiko Kobayashi,
Kaori Ishikawa,
Kazuto Nakada,
Masayuki Mori,
Yoshiaki Kikkawa,
Keizo Takenaga,
Noriko Toyama-Sorimachi,
Jun-Ichi Hayashi

Published: September 30, 2013
https://doi.org/10.1371/journal.pone.0075981

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