Silencing of Doublecortin-Like (DCL) Results in Decreased Mitochondrial Activity and Delayed Neuroblastoma Tumor Growth

Carla S. Verissimo; Rachel Elands; Sou Cheng; Dirk-Jan Saaltink; Judith P. ter Horst; Maria N. Alme; Chantal Pont; Bob van de Water; Bjarte Håvik; Carlos P. Fitzsimons; Erno Vreugdenhil

doi:10.1371/journal.pone.0075752

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Open Access

Peer-reviewed

Research Article

Silencing of Doublecortin-Like (DCL) Results in Decreased Mitochondrial Activity and Delayed Neuroblastoma Tumor Growth

Carla S. Verissimo ,

* E-mail: c.s.leiriaverissimo@umcutrecht.nl (CSV); e.vreugdenhil.HG@lumc.nl (EV)

Current address: Department of Molecular Cancer Research, Centre of Biomedical Genetics and Cancer Genomics Centre, University Medical Center Utrecht, Utrecht, The Netherlands

Affiliation Division of Medical Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, the Netherlands
⨯
Rachel Elands,

Affiliation Division of Medical Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, the Netherlands
⨯
Sou Cheng,

Affiliation Prosensa Therapeutics B.V., Leiden, the Netherlands
⨯
Dirk-Jan Saaltink,

Affiliation Division of Medical Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, the Netherlands
⨯
Judith P. ter Horst,

Affiliation Division of Medical Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, the Netherlands
⨯
Maria N. Alme,

Affiliation Department of Biomedicine, K. G. Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen, Bergen, Norway
⨯
Chantal Pont,

Affiliation Division of Toxicology, Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, the Netherlands
⨯
Bob van de Water,

Affiliation Division of Toxicology, Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, the Netherlands
⨯
Bjarte Håvik,

Affiliations Dr. E. Martens Research Group for Biological Psychiatry, Department of Clinical Medicine, University of Bergen, Bergen, Norway, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
⨯
Carlos P. Fitzsimons,

Affiliation Centre for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, the Netherlands
⨯
Erno Vreugdenhil

* E-mail: c.s.leiriaverissimo@umcutrecht.nl (CSV); e.vreugdenhil.HG@lumc.nl (EV)

Affiliations Division of Medical Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, the Netherlands, Department of Human Genetics, Migraine Research Group, Leiden University Medical Center, Leiden, the Netherlands
⨯

Silencing of Doublecortin-Like (DCL) Results in Decreased Mitochondrial Activity and Delayed Neuroblastoma Tumor Growth

Carla S. Verissimo,
Rachel Elands,
Sou Cheng,
Dirk-Jan Saaltink,
Judith P. ter Horst,
Maria N. Alme,
Chantal Pont,
Bob van de Water,
Bjarte Håvik,
Carlos P. Fitzsimons

Published: September 26, 2013
https://doi.org/10.1371/journal.pone.0075752

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