Identification of Leptospira interrogans Phospholipase C as a Novel Virulence Factor Responsible for Intracellular Free Calcium Ion Elevation during Macrophage Death

• Jing-Fang Zhao ,

  Contributed equally to this work with: Jing-Fang Zhao, Hong-Hu Chen

  Affiliations State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China, Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China, Depatment of Clinical Laboratory, Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, P.R. China

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• Hong-Hu Chen ,

  Contributed equally to this work with: Jing-Fang Zhao, Hong-Hu Chen

  Affiliation Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China

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• David M. Ojcius,

  Affiliation Health Sciences Research Institute and Department Molecular Cell Biology, University of California Merced, Merced, California, United States of America

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• Xin Zhao,

  Affiliation Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China

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• Dexter Sun,

  Affiliation Department of Neurology and Neuroscience, New York Presbyterian Hospital and Hospital for Special Surgery, Cornell University Weill Medical College, New York, New York, United States of America

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• Yu-Mei Ge,

  Affiliations State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China, Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China

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• Lin-Li Zheng,

  Affiliation Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China

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• Xu’ai Lin,

  Affiliations State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China, Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China

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• Lan-Juan Li ,

  * E-mail: ljli@zju.edu.cn (LJL); med_bp@zju.edu.cn (JY)

  Affiliation State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China

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• Jie Yan

  * E-mail: ljli@zju.edu.cn (LJL); med_bp@zju.edu.cn (JY)

  Affiliations State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China, Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China

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