A Low-Molecular-Weight Compound K7174 Represses Hepcidin: Possible Therapeutic Strategy against Anemia of Chronic Disease

Tohru Fujiwara; Takashi Ikeda; Yuki Nagasaka; Yoko Okitsu; Yuna Katsuoka; Noriko Fukuhara; Yasushi Onishi; Kenichi Ishizawa; Ryo Ichinohasama; Naohisa Tomosugi; Hideo Harigae

doi:10.1371/journal.pone.0075568

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Open Access

Peer-reviewed

Research Article

A Low-Molecular-Weight Compound K7174 Represses Hepcidin: Possible Therapeutic Strategy against Anemia of Chronic Disease

Tohru Fujiwara ,

* E-mail: fujiwara-to@apple.email.ne.jp

Affiliations Department of Hematology and Rheumatology, Tohoku University Graduate School, Sendai, Japan, Molecular Hematology/Oncology, Tohoku University Graduate School, Sendai, Japan
⨯
Takashi Ikeda,

Affiliation Department of Hematology and Rheumatology, Tohoku University Graduate School, Sendai, Japan
⨯
Yuki Nagasaka,

Affiliation Department of Hematology and Rheumatology, Tohoku University Graduate School, Sendai, Japan
⨯
Yoko Okitsu,

Affiliation Department of Hematology and Rheumatology, Tohoku University Graduate School, Sendai, Japan
⨯
Yuna Katsuoka,

Affiliation Department of Hematology and Rheumatology, Tohoku University Graduate School, Sendai, Japan
⨯
Noriko Fukuhara,

Affiliation Department of Hematology and Rheumatology, Tohoku University Graduate School, Sendai, Japan
⨯
Yasushi Onishi,

Affiliation Department of Hematology and Rheumatology, Tohoku University Graduate School, Sendai, Japan
⨯
Kenichi Ishizawa,

Affiliations Department of Hematology and Rheumatology, Tohoku University Graduate School, Sendai, Japan, Clinical Research, Innovation and Education Center, Tohoku University Hospital, Sendai, Japan
⨯
Ryo Ichinohasama,

Affiliation Hematopathology, Tohoku University Graduate School, Sendai, Japan
⨯
Naohisa Tomosugi,

Affiliation Aging Research Unit, Division of Advanced Medicine, Medical Research Institute, Kanazawa Medical College, Kanazawa, Japan
⨯
Hideo Harigae

Affiliations Department of Hematology and Rheumatology, Tohoku University Graduate School, Sendai, Japan, Molecular Hematology/Oncology, Tohoku University Graduate School, Sendai, Japan
⨯

A Low-Molecular-Weight Compound K7174 Represses Hepcidin: Possible Therapeutic Strategy against Anemia of Chronic Disease

Tohru Fujiwara,
Takashi Ikeda,
Yuki Nagasaka,
Yoko Okitsu,
Yuna Katsuoka,
Noriko Fukuhara,
Yasushi Onishi,
Kenichi Ishizawa,
Ryo Ichinohasama,
Naohisa Tomosugi

Published: September 27, 2013
https://doi.org/10.1371/journal.pone.0075568

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