Dual p38/JNK Mitogen Activated Protein Kinase Inhibitors Prevent Ozone-Induced Airway Hyperreactivity in Guinea Pigs

Open Access

Peer-reviewed

Research Article

Kirsten C. Verhein ,

* E-mail: verheinkc@niehs.nih.gov

Current address: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America

Affiliation Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon, United States of America
⨯
Francesco G. Salituro,

Current address: Sage Therapeutics, Cambridge, Massachusetts, United States of America

Affiliation Vertex Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America
⨯
Mark W. Ledeboer,

Affiliation Vertex Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America
⨯
Allison D. Fryer,

Affiliation Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, United States of America
⨯
David B. Jacoby

Affiliation Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, United States of America
⨯

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Ozone
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Acetylcholine
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Inflammation
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Muscarinic acetylcholine receptors
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Guinea pigs
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MAPK signaling cascades
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Heart rate
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Asthma
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