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Open Access

Peer-reviewed

Research Article

Established Thymic Epithelial Progenitor/Stem Cell-Like Cell Lines Differentiate into Mature Thymic Epithelial Cells and Support T Cell Development

Pengfei Chen ,

Contributed equally to this work with: Pengfei Chen, Jun Zhang

Affiliation Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Jun Zhang ,

Contributed equally to this work with: Pengfei Chen, Jun Zhang

Affiliation Department of Transfusion, First Affiliated Hospital of Bengbu Medical College, Anhui, China
⨯
Yu Zhan,

Affiliation Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Juanjuan Su,

Affiliation Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Yarui Du,

Affiliation State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Guoliang Xu,

Affiliation State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Yufang Shi,

Affiliation Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Ulrich Siebenlist,

Affiliation Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Xiaoren Zhang

* E-mail: xrzhang@sibs.ac.cn

Affiliation Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯

Established Thymic Epithelial Progenitor/Stem Cell-Like Cell Lines Differentiate into Mature Thymic Epithelial Cells and Support T Cell Development

Pengfei Chen,
Jun Zhang,
Yu Zhan,
Juanjuan Su,
Yarui Du,
Guoliang Xu,
Yufang Shi,
Ulrich Siebenlist,
Xiaoren Zhang

x

Published: September 23, 2013
https://doi.org/10.1371/journal.pone.0075222

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Thymus
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T cells
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Cell differentiation
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Epithelial cells
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Cloning
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Mouse models
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Thymocytes
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Transcription factors
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