Catabolism of Exogenous Lactate Reveals It as a Legitimate Metabolic Substrate in Breast Cancer

Kelly M. Kennedy; Peter M. Scarbrough; Anthony Ribeiro; Rachel Richardson; Hong Yuan; Pierre Sonveaux; Chelsea D. Landon; Jen-Tsan Chi; Salvatore Pizzo; Thies Schroeder; Mark W. Dewhirst

doi:10.1371/journal.pone.0075154

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Open Access

Peer-reviewed

Research Article

Catabolism of Exogenous Lactate Reveals It as a Legitimate Metabolic Substrate in Breast Cancer

Kelly M. Kennedy,

Affiliation Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Peter M. Scarbrough,

Affiliation Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Anthony Ribeiro,

Affiliation Duke University Shared Resources NMR Facility, Duke University, Durham, North Carolina, United States of America
⨯
Rachel Richardson,

Affiliation Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Hong Yuan,

Affiliation Department of Radiology, University of North Carolina, Chapel Hill, North Carolina, United States of America
⨯
Pierre Sonveaux,

Affiliation Pole of Pharmacology, Institut de Recherches Expérimentales et Cliniques (IREC), Université catholique de Louvain (UCL), Brussels, Belgium
⨯
Chelsea D. Landon,

Affiliation Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Jen-Tsan Chi,

Affiliations Institute of Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Salvatore Pizzo,

Affiliation Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Thies Schroeder ,

Contributed equally to this work with: Thies Schroeder, Mark W. Dewhirst

Affiliation Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Mark W. Dewhirst

Contributed equally to this work with: Thies Schroeder, Mark W. Dewhirst

* E-mail: mark.dewhirst@duke.edu

Affiliations Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯

Catabolism of Exogenous Lactate Reveals It as a Legitimate Metabolic Substrate in Breast Cancer

Kelly M. Kennedy,
Peter M. Scarbrough,
Anthony Ribeiro,
Rachel Richardson,
Hong Yuan,
Pierre Sonveaux,
Chelsea D. Landon,
Jen-Tsan Chi,
Salvatore Pizzo,
Thies Schroeder

Published: September 12, 2013
https://doi.org/10.1371/journal.pone.0075154

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