The Nociceptin/Orphanin FQ Receptor Antagonist UFP-101 Reduces Microvascular Inflammation to Lipopolysaccharide In Vivo

Zoë L. S. Brookes; Emily N. Stedman; Nicola J. Brown; Christopher P. Hebbes; Remo Guerrini; Girolamo Calo; Charles S. Reilly; David G. Lambert

doi:10.1371/journal.pone.0074943

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Open Access

Peer-reviewed

Research Article

The Nociceptin/Orphanin FQ Receptor Antagonist UFP-101 Reduces Microvascular Inflammation to Lipopolysaccharide In Vivo

Zoë L. S. Brookes ,

Contributed equally to this work with: Zoë L. S. Brookes, David G. Lambert

Affiliation Microcirculation Research Group, Department of Cardiovascular Sciences, University of Sheffield, Sheffield, United Kingdom
⨯
Emily N. Stedman,

Affiliation Microcirculation Research Group, Department of Cardiovascular Sciences, University of Sheffield, Sheffield, United Kingdom
⨯
Nicola J. Brown,

Affiliation Microcirculation Research Group, Department of Cardiovascular Sciences, University of Sheffield, Sheffield, United Kingdom
⨯
Christopher P. Hebbes,

Affiliation Department of Cardiovascular Sciences, Division of Anaesthesia, Critical Care and Pain Management, University of Leicester, Leicester Royal Infirmary, Leicester, United Kingdom
⨯
Remo Guerrini,

Affiliation Department of Pharmaceutical Sciences and Biotechnology Center, University of Ferrara, Ferrara, Italy
⨯
Girolamo Calo,

Affiliations Department of Pharmaceutical Sciences and Biotechnology Center, University of Ferrara, Ferrara, Italy, Department of Experimental and Clinical Medicine, Section of Pharmacology, University of Ferrara and Italian Institute of Neuroscience, Ferrara, Italy
⨯
Charles S. Reilly,

Affiliation Microcirculation Research Group, Department of Cardiovascular Sciences, University of Sheffield, Sheffield, United Kingdom
⨯
David G. Lambert

Contributed equally to this work with: Zoë L. S. Brookes, David G. Lambert

* E-mail: dgl3@leicester.ac.uk

Affiliation Department of Cardiovascular Sciences, Division of Anaesthesia, Critical Care and Pain Management, University of Leicester, Leicester Royal Infirmary, Leicester, United Kingdom
⨯

The Nociceptin/Orphanin FQ Receptor Antagonist UFP-101 Reduces Microvascular Inflammation to Lipopolysaccharide In Vivo

Zoë L. S. Brookes,
Emily N. Stedman,
Nicola J. Brown,
Christopher P. Hebbes,
Remo Guerrini,
Girolamo Calo,
Charles S. Reilly,
David G. Lambert

Published: September 23, 2013
https://doi.org/10.1371/journal.pone.0074943

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