Virulence Potential and Genome-Wide Characterization of Drug Resistant Streptococcus pneumoniae Clones Selected In Vivo by the 7-Valent Pneumococcal Conjugate Vaccine

Nelson Frazão; N. Luisa Hiller; Evan Powell; Josh Earl; Azad Ahmed; Raquel Sá-Leão; Hermínia de Lencastre; Garth D. Ehrlich; Alexander Tomasz

doi:10.1371/journal.pone.0074867

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Open Access

Peer-reviewed

Research Article

Virulence Potential and Genome-Wide Characterization of Drug Resistant Streptococcus pneumoniae Clones Selected In Vivo by the 7-Valent Pneumococcal Conjugate Vaccine

Nelson Frazão,

Affiliations Laboratory of Molecular Genetics, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal, Laboratory of Microbiology, The Rockefeller University, New York, New York, United States of America
⨯
N. Luisa Hiller,

Affiliations Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America, Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America
⨯
Evan Powell,

Affiliation Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America
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Josh Earl,

Affiliation Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America
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Azad Ahmed,

Affiliation Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America
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Raquel Sá-Leão,

Affiliation Laboratory of Molecular Microbiology of Human Pathogens, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal
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Hermínia de Lencastre,

Affiliations Laboratory of Molecular Genetics, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal, Laboratory of Microbiology, The Rockefeller University, New York, New York, United States of America
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Garth D. Ehrlich,

Affiliation Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America
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Alexander Tomasz

* E-mail: tomasz@mail.rockefeller.edu

Affiliation Laboratory of Microbiology, The Rockefeller University, New York, New York, United States of America
⨯

Virulence Potential and Genome-Wide Characterization of Drug Resistant Streptococcus pneumoniae Clones Selected In Vivo by the 7-Valent Pneumococcal Conjugate Vaccine

Nelson Frazão,
N. Luisa Hiller,
Evan Powell,
Josh Earl,
Azad Ahmed,
Raquel Sá-Leão,
Hermínia de Lencastre,
Garth D. Ehrlich,
Alexander Tomasz

Published: September 19, 2013
https://doi.org/10.1371/journal.pone.0074867

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