Deletion of the Vaccinia Virus Gene A46R, Encoding for an Inhibitor of TLR Signalling, Is an Effective Approach to Enhance the Immunogenicity in Mice of the HIV/AIDS Vaccine Candidate NYVAC-C

Beatriz Perdiguero; Carmen Elena Gómez; Mauro Di Pilato; Carlos Oscar S. Sorzano; Julie Delaloye; Thierry Roger; Thierry Calandra; Giuseppe Pantaleo; Mariano Esteban

doi:10.1371/journal.pone.0074831

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Peer-reviewed

Research Article

Deletion of the Vaccinia Virus Gene A46R, Encoding for an Inhibitor of TLR Signalling, Is an Effective Approach to Enhance the Immunogenicity in Mice of the HIV/AIDS Vaccine Candidate NYVAC-C

Beatriz Perdiguero,

Affiliation Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain
⨯
Carmen Elena Gómez,

Affiliation Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain
⨯
Mauro Di Pilato,

Affiliation Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain
⨯
Carlos Oscar S. Sorzano,

Affiliation Biocomputing Unit, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain
⨯
Julie Delaloye,

Affiliation Infectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
⨯
Thierry Roger,

Affiliation Infectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
⨯
Thierry Calandra,

Affiliation Infectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
⨯
Giuseppe Pantaleo,

Affiliation Division of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
⨯
Mariano Esteban

* E-mail: mesteban@cnb.csic.es

Affiliation Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain
⨯

Deletion of the Vaccinia Virus Gene A46R, Encoding for an Inhibitor of TLR Signalling, Is an Effective Approach to Enhance the Immunogenicity in Mice of the HIV/AIDS Vaccine Candidate NYVAC-C

Beatriz Perdiguero,
Carmen Elena Gómez,
Mauro Di Pilato,
Carlos Oscar S. Sorzano,
Julie Delaloye,
Thierry Roger,
Thierry Calandra,
Giuseppe Pantaleo,
Mariano Esteban

Published: September 17, 2013
https://doi.org/10.1371/journal.pone.0074831

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