Creatine Kinase-Overexpression Improves Myocardial Energetics, Contractile Dysfunction and Survival in Murine Doxorubicin Cardiotoxicity

Ashish Gupta; Cory Rohlfsen; Michelle K. Leppo; Vadappuram P. Chacko; Yibin Wang; Charles Steenbergen; Robert G. Weiss

doi:10.1371/journal.pone.0074675

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Peer-reviewed

Research Article

Creatine Kinase-Overexpression Improves Myocardial Energetics, Contractile Dysfunction and Survival in Murine Doxorubicin Cardiotoxicity

Ashish Gupta,

Affiliations Department of Medicine, Division of Cardiology, the Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Radiology, Division of Magnetic Resonance Research, the Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Cory Rohlfsen,

Affiliation Department of Medicine, Division of Cardiology, the Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Michelle K. Leppo,

Affiliation Department of Medicine, Division of Cardiology, the Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Vadappuram P. Chacko,

Affiliation Department of Radiology, Division of Magnetic Resonance Research, the Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Yibin Wang,

Affiliation University of California Los Angeles, Los Angeles, California, United States of America
⨯
Charles Steenbergen,

Affiliation Department of Pathology, the Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Robert G. Weiss

* E-mail: rweiss@jhmi.edu

Affiliations Department of Medicine, Division of Cardiology, the Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Radiology, Division of Magnetic Resonance Research, the Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯

Creatine Kinase-Overexpression Improves Myocardial Energetics, Contractile Dysfunction and Survival in Murine Doxorubicin Cardiotoxicity

Ashish Gupta,
Cory Rohlfsen,
Michelle K. Leppo,
Vadappuram P. Chacko,
Yibin Wang,
Charles Steenbergen,
Robert G. Weiss

Published: October 1, 2013
https://doi.org/10.1371/journal.pone.0074675

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