Pim-1 Kinase Phosphorylates and Stabilizes 130 kDa FLT3 and Promotes Aberrant STAT5 Signaling in Acute Myeloid Leukemia with FLT3 Internal Tandem Duplication

Open Access

Peer-reviewed

Research Article

Karthika Natarajan ,

Contributed equally to this work with: Karthika Natarajan, Yingqiu Xie

Affiliation Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland, United States of America
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Yingqiu Xie ,

Contributed equally to this work with: Karthika Natarajan, Yingqiu Xie

Affiliation Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland, United States of America
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Mehmet Burcu,

Affiliation Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland, United States of America
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Douglas E. Linn,

Affiliation Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
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Yun Qiu,

Affiliations Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland, United States of America, Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
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Maria R. Baer

* E-mail: mbaer@umm.edu

Affiliations Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland, United States of America, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
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Phosphorylation
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Serine
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Immunoprecipitation
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Glycosylation
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Immunoblotting
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STAT signaling
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Apoptosis
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Cell signaling
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