MiR-499 Regulates Cell Proliferation and Apoptosis during Late-Stage Cardiac Differentiation via Sox6 and Cyclin D1

Xianhui Li; Jiaji Wang; Zhuqing Jia; Qinghua Cui; Chenguang Zhang; Weiping Wang; Ping Chen; Kangtao Ma; Chunyan Zhou

doi:10.1371/journal.pone.0074504

Loading metrics

Open Access

Peer-reviewed

Research Article

MiR-499 Regulates Cell Proliferation and Apoptosis during Late-Stage Cardiac Differentiation via Sox6 and Cyclin D1

Xianhui Li ,

Contributed equally to this work with: Xianhui Li, Jiaji Wang

Current address: Department of Biochemistry and Molecular Biology, Logistics College of Chinese People’s Armed Police Forces, Tianjin, China

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education of China, Peking University, Beijing, China
⨯
Jiaji Wang ,

Contributed equally to this work with: Xianhui Li, Jiaji Wang

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education of China, Peking University, Beijing, China
⨯
Zhuqing Jia ,

* E-mail: chunyanzhou@bjmu.edu.cn (CZ); zhuqingjia@bjmu.edu.cn (ZJ)

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education of China, Peking University, Beijing, China
⨯
Qinghua Cui,

Affiliation Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University, Beijing, China
⨯
Chenguang Zhang,

Current address: Department of Medical Genetics, Capital Medical University, Beijing, China

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education of China, Peking University, Beijing, China
⨯
Weiping Wang,

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education of China, Peking University, Beijing, China
⨯
Ping Chen,

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education of China, Peking University, Beijing, China
⨯
Kangtao Ma,

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education of China, Peking University, Beijing, China
⨯
Chunyan Zhou

* E-mail: chunyanzhou@bjmu.edu.cn (CZ); zhuqingjia@bjmu.edu.cn (ZJ)

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education of China, Peking University, Beijing, China
⨯

MiR-499 Regulates Cell Proliferation and Apoptosis during Late-Stage Cardiac Differentiation via Sox6 and Cyclin D1

Xianhui Li,
Jiaji Wang,
Zhuqing Jia,
Qinghua Cui,
Chenguang Zhang,
Weiping Wang,
Ping Chen,
Kangtao Ma,
Chunyan Zhou

Published: September 11, 2013
https://doi.org/10.1371/journal.pone.0074504

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cell differentiation
Is the Subject Area "Cell differentiation" applicable to this article?

Thanks for your feedback.
Cardiomyocytes
Is the Subject Area "Cardiomyocytes" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Cyclins
Is the Subject Area "Cyclins" applicable to this article?

Thanks for your feedback.
Cell cycle and cell division
Is the Subject Area "Cell cycle and cell division" applicable to this article?

Thanks for your feedback.
Flow cytometry
Is the Subject Area "Flow cytometry" applicable to this article?

Thanks for your feedback.
Cell proliferation
Is the Subject Area "Cell proliferation" applicable to this article?

Thanks for your feedback.