miR-221/222 Target the DNA Methyltransferase MGMT in Glioma Cells

Cristina Quintavalle; Davide Mangani; Giuseppina Roscigno; Giulia Romano; Angel Diaz-Lagares; Margherita Iaboni; Elvira Donnarumma; Danilo Fiore; Pasqualino De Marinis; Ylermi Soini; Manel Esteller; Gerolama Condorelli

doi:10.1371/journal.pone.0074466

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Open Access

Peer-reviewed

Research Article

miR-221/222 Target the DNA Methyltransferase MGMT in Glioma Cells

Cristina Quintavalle ,

Contributed equally to this work with: Cristina Quintavalle, Davide Mangani

Affiliations Department of Molecular Medicine and Medical Biotechnology, "Federico II” University ofNaples, Naples, Italy, IEOS, CNR, Naples, Italy
⨯
Davide Mangani ,

Contributed equally to this work with: Cristina Quintavalle, Davide Mangani

Affiliation Department of Molecular Medicine and Medical Biotechnology, "Federico II” University ofNaples, Naples, Italy
⨯
Giuseppina Roscigno,

Affiliations Department of Molecular Medicine and Medical Biotechnology, "Federico II” University ofNaples, Naples, Italy, IEOS, CNR, Naples, Italy
⨯
Giulia Romano,

Affiliation Fondazione IRCCS SDN, Naples, Italy
⨯
Angel Diaz-Lagares,

Affiliation Epigenetic and Cancer Biology Program (PEBC) IDIBELL, Hospital Duran i Reynals, Barcelona, Spain
⨯
Margherita Iaboni,

Affiliation Department of Molecular Medicine and Medical Biotechnology, "Federico II” University ofNaples, Naples, Italy
⨯
Elvira Donnarumma,

Affiliation Fondazione IRCCS SDN, Naples, Italy
⨯
Danilo Fiore,

Affiliation Department of Molecular Medicine and Medical Biotechnology, "Federico II” University ofNaples, Naples, Italy
⨯
Pasqualino De Marinis,

Affiliation Ospedale Cardarelli, Naples, Italy
⨯
Ylermi Soini,

Affiliation Department of Pathology and Forensic Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, School of Medicine, Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland
⨯
Manel Esteller,

Affiliation Epigenetic and Cancer Biology Program (PEBC) IDIBELL, Hospital Duran i Reynals, Barcelona, Spain
⨯
Gerolama Condorelli

* E-mail: gecondor@unina.it

Affiliations Department of Molecular Medicine and Medical Biotechnology, "Federico II” University ofNaples, Naples, Italy, IEOS, CNR, Naples, Italy
⨯

miR-221/222 Target the DNA Methyltransferase MGMT in Glioma Cells

Cristina Quintavalle,
Davide Mangani,
Giuseppina Roscigno,
Giulia Romano,
Angel Diaz-Lagares,
Margherita Iaboni,
Elvira Donnarumma,
Danilo Fiore,
Pasqualino De Marinis,
Ylermi Soini

Published: September 19, 2013
https://doi.org/10.1371/journal.pone.0074466

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DNA methylation
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Transfection
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Glioblastoma multiforme
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DNA damage
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DNA repair
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Glioma cells
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Methylation
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Polymerase chain reaction
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