Combined Inhibition of p97 and the Proteasome Causes Lethal Disruption of the Secretory Apparatus in Multiple Myeloma Cells

Holger W. Auner; Anne Marie Moody; Theresa H. Ward; Marianne Kraus; Enrico Milan; Philippa May; Aristeidis Chaidos; Christoph Driessen; Simone Cenci; Francesco Dazzi; Amin Rahemtulla; Jane F. Apperley; Anastasios Karadimitris; Niall Dillon

doi:10.1371/journal.pone.0074415

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Peer-reviewed

Research Article

Combined Inhibition of p97 and the Proteasome Causes Lethal Disruption of the Secretory Apparatus in Multiple Myeloma Cells

Holger W. Auner ,

* E-mail: holger.auner04@imperial.ac.uk (HWA); niall.dillon@csc.mrc.ac.uk (ND)

Affiliations Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom, Centre for Haematology, Department of Medicine, Imperial College London, London, United Kingdom
⨯
Anne Marie Moody,

Affiliation Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom
⨯
Theresa H. Ward,

Affiliation Immunology and Infection Department, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Marianne Kraus,

Affiliation Kantonsspital, St. Gallen, St. Gallen, Switzerland
⨯
Enrico Milan,

Affiliation Age Related Diseases Group, Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy
⨯
Philippa May,

Affiliation Centre for Haematology, Department of Medicine, Imperial College London, London, United Kingdom
⨯
Aristeidis Chaidos,

Affiliation Centre for Haematology, Department of Medicine, Imperial College London, London, United Kingdom
⨯
Christoph Driessen,

Affiliation Kantonsspital, St. Gallen, St. Gallen, Switzerland
⨯
Simone Cenci,

Affiliation Age Related Diseases Group, Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy
⨯
Francesco Dazzi,

Affiliation Centre for Haematology, Department of Medicine, Imperial College London, London, United Kingdom
⨯
Amin Rahemtulla,

Affiliation Centre for Haematology, Department of Medicine, Imperial College London, London, United Kingdom
⨯
Jane F. Apperley,

Affiliation Centre for Haematology, Department of Medicine, Imperial College London, London, United Kingdom
⨯
Anastasios Karadimitris,

Affiliation Centre for Haematology, Department of Medicine, Imperial College London, London, United Kingdom
⨯
Niall Dillon

* E-mail: holger.auner04@imperial.ac.uk (HWA); niall.dillon@csc.mrc.ac.uk (ND)

Affiliation Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom
⨯

Combined Inhibition of p97 and the Proteasome Causes Lethal Disruption of the Secretory Apparatus in Multiple Myeloma Cells

Holger W. Auner,
Anne Marie Moody,
Theresa H. Ward,
Marianne Kraus,
Enrico Milan,
Philippa May,
Aristeidis Chaidos,
Christoph Driessen,
Simone Cenci,
Francesco Dazzi

Published: September 17, 2013
https://doi.org/10.1371/journal.pone.0074415

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Proteasomes
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Apoptosis
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Protein translation
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Cell disruption
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Fibroblasts
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Signal inhibition
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Cell staining
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Multiple myeloma
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