Methylglyoxal Induces Platelet Hyperaggregation and Reduces Thrombus Stability by Activating PKC and Inhibiting PI3K/Akt Pathway

Open Access

Peer-reviewed

Research Article

Karin Hadas ,

Contributed equally to this work with: Karin Hadas, Voahanginirina Randriamboavonjy

Affiliation Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany
⨯
Voahanginirina Randriamboavonjy ,

Contributed equally to this work with: Karin Hadas, Voahanginirina Randriamboavonjy

* E-mail: voahangy@vrc.uni-frankfurt.de

Affiliation Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany
⨯
Amro Elgheznawy,

Affiliation Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany
⨯
Alexander Mann,

Affiliation Endokrinologikum Frankfurt, Frankfurt am Main, Germany
⨯
Ingrid Fleming

Affiliation Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany
⨯

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Platelets
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Integrins
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Platelet aggregation
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Diabetes mellitus
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Platelet activation
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Thrombin
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Phosphorylation
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Collagens
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