Ribosomal S6 Kinase 2 (RSK2) Maintains Genomic Stability by Activating the Atm/p53-Dependent DNA Damage Pathway

Han Chi Lim; Li Xie; Wei Zhang; Rong Li; Zhong-Can Chen; Guang-Zhi Wu; Shu-Sen Cui; Eng King Tan; Li Zeng

doi:10.1371/journal.pone.0074334

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Open Access

Peer-reviewed

Research Article

Ribosomal S6 Kinase 2 (RSK2) Maintains Genomic Stability by Activating the Atm/p53-Dependent DNA Damage Pathway

Han Chi Lim,

Affiliation Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore
⨯
Li Xie,

Affiliation Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore
⨯
Wei Zhang,

Affiliation Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore
⨯
Rong Li,

Affiliations Experimental Therapeutics Centre, c/o Biomedical Sciences Institutes (BMSI), A*STAR, Singapore, Singapore, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
⨯
Zhong-Can Chen,

Affiliation Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
⨯
Guang-Zhi Wu,

Affiliation Department of Hand-surgery, China-Japan Union Hospital, Jilin University, Changchun City, Jinlin Province, People's Republic of China
⨯
Shu-Sen Cui,

Affiliation Department of Hand-surgery, China-Japan Union Hospital, Jilin University, Changchun City, Jinlin Province, People's Republic of China
⨯
Eng King Tan,

Affiliations Research Department, National Neuroscience Institute, Singapore, Singapore, Neurology Department, National Neuroscience Institute, Singapore, Singapore, Neuroscience & Behavioral Disorders program, DUKE-NUS Graduate Medical School, Singapore, Singapore
⨯
Li Zeng

* E-mail: Li_ZENG@nni.com.sg

Affiliations Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore, Neuroscience & Behavioral Disorders program, DUKE-NUS Graduate Medical School, Singapore, Singapore
⨯

Ribosomal S6 Kinase 2 (RSK2) Maintains Genomic Stability by Activating the Atm/p53-Dependent DNA Damage Pathway

Han Chi Lim,
Li Xie,
Wei Zhang,
Rong Li,
Zhong-Can Chen,
Guang-Zhi Wu,
Shu-Sen Cui,
Eng King Tan,
Li Zeng

Published: September 23, 2013
https://doi.org/10.1371/journal.pone.0074334

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