The Design and In Vivo Evaluation of Engineered I-OnuI-Based Enzymes for HEG Gene Drive

• Yuk-Sang Chan ,

  Contributed equally to this work with: Yuk-Sang Chan, Ryo Takeuchi, Jordan Jarjour, David S. Huen

  Affiliation Department of Genetics, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom

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• Ryo Takeuchi ,

  Contributed equally to this work with: Yuk-Sang Chan, Ryo Takeuchi, Jordan Jarjour, David S. Huen

  Affiliations Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Northwest Genome Engineering Consortium, Seattle, Washington, United States of America

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• Jordan Jarjour ,

  Contributed equally to this work with: Yuk-Sang Chan, Ryo Takeuchi, Jordan Jarjour, David S. Huen

  Affiliation Pregenen Inc., Seattle, Washington, United States of America

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• David S. Huen ,

  Contributed equally to this work with: Yuk-Sang Chan, Ryo Takeuchi, Jordan Jarjour, David S. Huen

  * E-mail: david.s.huen@gmail.com

  Current address: Department of Applied Sciences, University of Wolverhampton, Wolverhampton, United Kingdom

  Affiliation Department of Genetics, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom

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• Barry L. Stoddard,

  Affiliations Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Northwest Genome Engineering Consortium, Seattle, Washington, United States of America

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• Steven Russell

  Affiliations Department of Genetics, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom, Cambridge Systems Biology Centre, Cambridge, Cambridgeshire, United Kingdom

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