Serine Protease HTRA1 Antagonizes Transforming Growth Factor-β Signaling by Cleaving Its Receptors and Loss of HTRA1 In Vivo Enhances Bone Formation

Julie R. Graham; Angela Chamberland; Qingcong Lin; X. Jian Li; David Dai; Weilan Zeng; Mark S. Ryan; Moisés A. Rivera-Bermúdez; Carl R. Flannery; Zhiyong Yang

doi:10.1371/journal.pone.0074094

Loading metrics

Open Access

Peer-reviewed

Research Article

Serine Protease HTRA1 Antagonizes Transforming Growth Factor-β Signaling by Cleaving Its Receptors and Loss of HTRA1 In Vivo Enhances Bone Formation

Julie R. Graham ,

Contributed equally to this work with: Julie R. Graham, Angela Chamberland

Affiliation Inflammation and Remodeling Research Unit, Pfizer BioTherapeutics Research, Cambridge, Massachusetts, United States of America
⨯
Angela Chamberland ,

Contributed equally to this work with: Julie R. Graham, Angela Chamberland

Affiliation Inflammation and Remodeling Research Unit, Pfizer BioTherapeutics Research, Cambridge, Massachusetts, United States of America
⨯
Qingcong Lin,

Affiliation Global BioTherapeutic Technologies, Pfizer BioTherapeutics Research, Cambridge, Massachusetts, United States of America
⨯
X. Jian Li,

Affiliation Inflammation and Remodeling Research Unit, Pfizer BioTherapeutics Research, Cambridge, Massachusetts, United States of America
⨯
David Dai,

Affiliation Inflammation and Remodeling Research Unit, Pfizer BioTherapeutics Research, Cambridge, Massachusetts, United States of America
⨯
Weilan Zeng,

Affiliation Inflammation and Remodeling Research Unit, Pfizer BioTherapeutics Research, Cambridge, Massachusetts, United States of America
⨯
Mark S. Ryan,

Affiliation Immunoscience Research Unit, Pfizer BioTherapeutics Research, Cambridge, Massachusetts, United States of America
⨯
Moisés A. Rivera-Bermúdez,

Affiliation Inflammation and Remodeling Research Unit, Pfizer BioTherapeutics Research, Cambridge, Massachusetts, United States of America
⨯
Carl R. Flannery,

Affiliation Inflammation and Remodeling Research Unit, Pfizer BioTherapeutics Research, Cambridge, Massachusetts, United States of America
⨯
Zhiyong Yang

* E-mail: zhiyong.yang@pfizer.com

Affiliation Inflammation and Remodeling Research Unit, Pfizer BioTherapeutics Research, Cambridge, Massachusetts, United States of America
⨯

Serine Protease HTRA1 Antagonizes Transforming Growth Factor-β Signaling by Cleaving Its Receptors and Loss of HTRA1 In Vivo Enhances Bone Formation

Julie R. Graham,
Angela Chamberland,
Qingcong Lin,
X. Jian Li,
David Dai,
Weilan Zeng,
Mark S. Ryan,
Moisés A. Rivera-Bermúdez,
Carl R. Flannery,
Zhiyong Yang

Published: September 11, 2013
https://doi.org/10.1371/journal.pone.0074094

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Bone development
Is the Subject Area "Bone development" applicable to this article?

Thanks for your feedback.
Genetically modified animals
Is the Subject Area "Genetically modified animals" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Small interfering RNA
Is the Subject Area "Small interfering RNA" applicable to this article?

Thanks for your feedback.
Signal inhibition
Is the Subject Area "Signal inhibition" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
HeLa cells
Is the Subject Area "HeLa cells" applicable to this article?

Thanks for your feedback.
SMAD signaling
Is the Subject Area "SMAD signaling" applicable to this article?

Thanks for your feedback.